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Pharmaceutical Chemistry Scholarly Works: Recent submissions
Now showing items 321-340 of 358
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Bcl-2 Suppresses Sarcoplasmic/Endoplasmic Reticulum Ca21-ATPase Expression in Cystic Fibrosis Airways
(Americal Thoracic Society, 2009)Rationale: Modulation of the activity of sarcoendoplasmic reticulum calcium ATPase (SERCA) can profoundly affect Ca21 homeostasis. Although altered calcium homeostasis is a characteristic of cystic fibrosis (CF), the role ... -
Crystallization and preliminary X-ray analysis of human placental S-adenosylhomocysteine hydrolase
(International Union of Crystallography, 1997)A recombinant form of human placental S-adenosylhomocysteine (AdoHcy) hydrolase expressed in E. coli, which was inactivated by a type-I mechanism-based inhibitor, has been crystallized using the hanging-drop vapour-diffusion ... -
Biophysical Characterization of Chlamydia trachomatis CT584 Supports Its Potential Role as a Type III Secretion Needle Tip Protein
(American Chemical Society, 2009-11)Chlamydia are obligate intracellular bacterial pathogens that cause a variety of diseases. Likemany Gram-negative bacteria, they employ type III secretion systems (T3SS) for invasion, establishing and maintaining their ... -
Lymphatic trafficking kinetics and near-infrared imaging using star polymer architectures with controlled anionic character
(Elsevier, 2012-04-22)Targeted lymphatic delivery of nanoparticles for drug delivery and imaging is primarily dependent on size and charge. Prior studies have observed increased lymphatic uptake and retentions of over 48 hrs for negatively ... -
Chemotherapy of Second stage Human african Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
(Public Library of Science, 2015-02-05)Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central ... -
Tyrosine Modifications in Aging
(Mary Ann Liebert, Inc., 2012-12-01)Significance: The understanding of physiological and pathological processes involving protein oxidation, particularly under conditions of aging and oxidative stress, can be aided by proteomic identification of proteins ... -
Bcl-2 Suppresses Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase Expression in Cystic Fibrosis Airways
(American Thoracic Society, 2009-05-01)Rationale: Modulation of the activity of sarcoendoplasmic reticulum calcium ATPase (SERCA) can profoundly affect Ca2+ homeostasis. Although altered calcium homeostasis is a characteristic of cystic fibrosis (CF), the role ... -
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
(American Society for Clinical Investigation, 2008-02-01)Neurodegeneration in familial amyotrophic lateral sclerosis (ALS) is associated with enhanced redox stress caused by dominant mutations in superoxide dismutase–1 (SOD1). SOD1 is a cytosolic enzyme that facilitates the ... -
IpaD Localizes to the Tip of the Type III Secretion System Needle of Shigella flexneri
(American Society for Microbiology, 2006-08)Shigella flexneri, the causative agent of shigellosis, is a gram-negative bacterial pathogen that initiates infection by invading cells within the colonic epithelium. Contact with host cell surfaces induces a rapid burst ... -
Analytical and Biological Characterization of Supercoiled Plasmids Purified by Various Chromatographic Techniques
(Mary Ann Liebert, Inc., 2005-12-06)Supercoiled plasmids are an important component of gene-based delivery vehicles. A number of production methods for clinical applications have been developed, each resulting in very high-quality product with low levels of ... -
In vivo photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma using a near-infrared caspase-9 probe
(Society of Photo-optical Instrumentation Engineers, 2011-10-27)Anti-cancer drugs typically exert their pharmacological effect on tumors by inducing apoptosis, or programmed cell death, within the cancer cells. However, no tools exist in the clinic for detecting apoptosis in real time. ... -
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun
(Portland Press Limited, 2012-11-06)Modulating molecular chaperones is emerging as an attractive approach to treat neurodegenerative diseases associated with protein aggregation, DPN (diabetic peripheral neuropathy) and possibly, demyelinating neuropathies. ... -
DB-PABP: a database of polyanion-binding proteins
(Oxford University Press, 2007-10-04)The interactions between polyanions (PAs) and polyanion-binding proteins (PABPs) have been found to play significant roles in many essential biological processes including intracellular organization, transport and protein ... -
Neuroprotective Effects of Calmodulin Peptide 76-121aa: Disruption of Calmodulin Binding to Mutant Huntingtin
(International Soceity of Neuropathology, 2009-03-11)Huntington's disease (HD) is a neurodegenerative disease caused by mutant huntingtin protein containing an expanded polyglutamine tract, which may cause abnormal protein–protein interactions such as increased association ... -
Pharmacokinetic Evaluation of a DSPE-PEG2000 Micellar Formulation of Ridaforolimus in Rat
(MDPI, 2012-12-27)The rapamycin analog, ridaforolimus, has demonstrated potent anti-proliferative effects in cancer treatment, and it currently is being evaluated in a range of clinical cancer studies. Ridaforolimus is an extremely lipophilic ... -
Impact of Molecular Weight on Lymphatic Drainage of a Biopolymer-Based Imaging Agent
(MDPI, 2012-05-23)New lymphatic imaging technologies are needed to better assess immune function and cancer progression and treatment. Lymphatic uptake depends mainly on particle size (10–100 nm) and charge. The size of carriers for imaging ... -
Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis
(Public Library of Science, 2013-06-06)There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs ... -
Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis
(Public Library of Science, 2012-07-24)Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second ... -
Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full-Length Dimer
(Public Library of Science, 2009-03-20)Hsp90 is a molecular chaperone essential for protein folding and activation in normal homeostasis and stress response. ATP binding and hydrolysis facilitate Hsp90 conformational changes required for client activation. Hsp90 ... -
In Silico Classification of Proteins from Acidic and Neutral Cytoplasms
(Public Library of Science, 2012-09-26)Protein acidostability is a common problem in biopharmaceutical and other industries. However, it remains a great challenge to engineer proteins for enhanced acidostability because our knowledge of protein acidostabilization ...