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dc.contributor.authorGe, Haibo
dc.contributor.authorVasandani, Veena
dc.contributor.authorHuff, Jacquelyn K.
dc.contributor.authorAudus, Kenneth L.
dc.contributor.authorHimes, Richard H.
dc.contributor.authorSeelig, Anna
dc.contributor.authorGeorg, Gunda I.
dc.date.accessioned2011-05-20T21:46:11Z
dc.date.available2011-05-20T21:46:11Z
dc.date.issued2006
dc.identifier.citationGe, H., Vasandani, V., Huff, J.K., Audus, K.L., Himes, R.H., Seelig, A., and Georg, G.I. (2006) Synthesis and interactions of 7-deoxy-, 10-deacetoxy and 7,10-dideoxypaclitaxel with MCF7-ADR cancer cells and bovine brain microvessel endothelial cells. Bioorg. Med. Chem. Lett., 16, 433-436. PMID: 16271474 http://dx.doi.org/10.1016/j.bmcl.2005.09.043
dc.identifier.urihttp://hdl.handle.net/1808/7486
dc.descriptionPlease note that this is an author-produced PDF of an article accepted for publication following peer review. The publisher version is available on its site.
dc.description.abstract7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7-deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with Pglycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel. ©2000 Elsevier Science Ltd. All rights reserved.
dc.language.isoen_US
dc.publisherElsevier
dc.titleSynthesis and Interactions of 7-Deoxy-, 10-Deacetoxy, and 10-Deacetoxy-7-Deoxypaclitaxel with NCI/ADR-RES Cancer Cells and Bovine Brain Microvessel Endothelial Cells
dc.typeArticle
kusw.kuauthorAudus, Kenneth L.
kusw.kudepartmentSchool of Pharmacy
kusw.oastatusfullparticipation
dc.identifier.doi10.1016/j.bmcl.2005.09.043
kusw.oaversionScholarly/refereed, author accepted manuscript
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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