dc.contributor.author | Ge, Haibo | |
dc.contributor.author | Vasandani, Veena | |
dc.contributor.author | Huff, Jacquelyn K. | |
dc.contributor.author | Audus, Kenneth L. | |
dc.contributor.author | Himes, Richard H. | |
dc.contributor.author | Seelig, Anna | |
dc.contributor.author | Georg, Gunda I. | |
dc.date.accessioned | 2011-05-20T21:46:11Z | |
dc.date.available | 2011-05-20T21:46:11Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Ge, H., Vasandani, V., Huff, J.K., Audus, K.L., Himes, R.H., Seelig, A., and Georg, G.I. (2006) Synthesis and interactions of 7-deoxy-, 10-deacetoxy and 7,10-dideoxypaclitaxel with MCF7-ADR cancer cells and bovine brain microvessel endothelial cells. Bioorg. Med. Chem. Lett., 16, 433-436. PMID: 16271474 http://dx.doi.org/10.1016/j.bmcl.2005.09.043 | |
dc.identifier.uri | http://hdl.handle.net/1808/7486 | |
dc.description | Please note that this is an author-produced PDF of an article accepted for publication following peer review. The publisher version is available on its site. | |
dc.description.abstract | 7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7-deoxypaclitaxel were prepared and evaluated for their ability
to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with Pglycoprotein
in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity
against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy
compounds having less interaction than paclitaxel and 7-deoxypaclitaxel. ©2000 Elsevier Science Ltd. All rights reserved. | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | |
dc.title | Synthesis and Interactions of 7-Deoxy-, 10-Deacetoxy, and 10-Deacetoxy-7-Deoxypaclitaxel with NCI/ADR-RES Cancer Cells and Bovine Brain Microvessel Endothelial Cells | |
dc.type | Article | |
kusw.kuauthor | Audus, Kenneth L. | |
kusw.kudepartment | School of Pharmacy | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1016/j.bmcl.2005.09.043 | |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess | |