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dc.contributor.authorYoung, Amber M.
dc.contributor.authorAllen, Courtni E.
dc.contributor.authorAudus, Kenneth L.
dc.date.accessioned2011-04-14T18:25:50Z
dc.date.available2011-04-14T18:25:50Z
dc.date.issued2003
dc.identifier.citationYoung, A.M., Allen, C.E., and Audus, K.L.* (2003) Efflux transporters of the placenta. Advanced Drug Delivery Reviews 55, 125-132. PMID: 12535577
dc.identifier.urihttp://hdl.handle.net/1808/7380
dc.descriptionThis is the author's accepted manuscript, post peer review. For the published version, please see the link in this record.
dc.description.abstractThe use of pharmaceuticals during pregnancy is often a necessity for the health of the mother. Until recently, the placenta was viewed as a passive organ through which molecules are passed indiscriminately between mother and fetus. In reality, the placenta contains a plethora of transporters, some of which appear to be specifically dedicated to removal of xenobiotics and toxic endogenous compounds. Drug efflux transporters such as P-glycoprotein (P-gp), several multidrug resistant associated proteins (MRPs) and breast cancer resistant protein (BCRP) may provide mechanisms that protect the developing fetus. Bile acid transporters may also play a role in exporting compounds back into the maternal compartment. Steroid hormones directly influence the level of expression and function in some of these transporters. Investigating the link between the hormones of pregnancy and these drug efflux transporters is one possible key in developing strategies to deliver drugs to the mother with minimal fetal risk.
dc.description.sponsorshipThis research was supported by NIH grants P01HD-3-9878 and N01DA-4-7405.
dc.publisherElsevier
dc.subjectP-glycoprotein
dc.subjectMDR1
dc.subjectMRP
dc.subjectBCRP
dc.subjectDrug efflux
dc.subjectPlacental barrier
dc.subjectMultidrug resistance
dc.titleEfflux transporters of the placenta
dc.typeArticle
kusw.kuauthorAudus, Kenneth L.
kusw.kudepartmentSchool of Pharmacy
kusw.oastatusna
dc.identifier.doi10.1016/S0169-409X(02)00174-6
kusw.oaversionScholarly/refereed, author accepted manuscript
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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