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dc.contributor.advisorWan, Yu-Jui Yvonne
dc.contributor.authorBu, Pengli
dc.date.accessioned2009-08-07T21:49:13Z
dc.date.available2009-08-07T21:49:13Z
dc.date.issued2009-04-07
dc.date.submitted2009
dc.identifier.otherhttp://dissertations.umi.com/ku:10274
dc.identifier.urihttp://hdl.handle.net/1808/5385
dc.description.abstractRetinoids, derivatives of vitamin A, are important signaling molecules regulating cellular homeostasis including differentiation, apoptosis, and proliferation. In this dissertation, we examined the versatile effects of retinoids on human liver cell lines and mouse livers by genetic and biochemical approaches. The overall finding is that retinoids can cause opposing effects in liver cells. These effects are retinoid-specific, mediated by distinct nuclear receptors, and depend on intrinsic cellular settings. The first part of this dissertation studies the mechanism underlying the differential susceptibilities of human liver cancer cells to the apoptotic effect of a synthetic retinoid, fenretinide. The findings establish a role for the nuclear receptors RARβ; and Nur77 in mediating fenretinide effect. The second part of this dissertation investigates the mechanism responsible for 13-cis retinoic acid-induced liver cell proliferation. The results demonstrate that the activation of a signaling cascade PPARβ;/PDK-1/Akt is responsible for 13-cis retinoic acid-induced proliferation of liver cells.
dc.format.extent193 pages
dc.language.isoEN
dc.publisherUniversity of Kansas
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
dc.subjectHealth sciences
dc.subjectToxicology
dc.subjectPharmacology
dc.subjectApoptosis
dc.subjectHepatocyte
dc.subjectNuclear receptors
dc.subjectProliferation
dc.subjectRetinoid
dc.titleRETINOID-INDUCED APOPTOSIS AND PROLIFERATION OF HEPATOCYTES ARE MEDIATED BY DISTINCT NUCLEAR RECEPTORS
dc.typeDissertation
dc.contributor.cmtememberGuo, Grace
dc.contributor.cmtememberHagenbuch, Bruno
dc.contributor.cmtememberPazdernik, Thomas L.
dc.contributor.cmtememberZhu, Hao
dc.thesis.degreeDisciplinePharmacology, Toxicology & Therapeutics
dc.thesis.degreeLevelPh.D.
kusw.oastatusna
dc.identifier.orcidhttps://orcid.org/0000-0003-2576-0607
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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