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dc.contributor.advisorKrise, Jeffrey P
dc.contributor.authorKaufmann, Allyn
dc.date.accessioned2009-02-02T05:58:09Z
dc.date.available2009-02-02T05:58:09Z
dc.date.issued2008-01-01
dc.date.submitted2008
dc.identifier.otherhttp://dissertations.umi.com/ku:10116
dc.identifier.urihttp://hdl.handle.net/1808/4339
dc.description.abstractMutations in the lysosome membrane protein Niemann-Pick C1 (NPC1) are known to cause a generalized block in retrograde vesicle-mediated transport from the lysosome, resulting in the hyper-accumulation of multiple lysosomal cargos. As a result, the true substrate of NPC1 is controversial and not fully understood at the current time. An important, yet often overlooked, category of lysosomal cargo includes the vast array of small molecular weight amine-containing molecules that are substrates for ion trapping in the highly acidic organelle lumen. In this dissertation, we provide experimental evidence to support a novel functional role for NPC1 involving the intracellular trafficking of amine-containing molecules.
dc.format.extent265 pages
dc.language.isoEN
dc.publisherUniversity of Kansas
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
dc.subjectPharmaceutical chemistry
dc.subjectAmine
dc.subjectLate endosome
dc.subjectLysosomes
dc.subjectNiemann-pick c1
dc.subjectNpc1
dc.subjectRetrograde traffic
dc.titleThe Niemann-Pick C1 Protein Functions in Regulating Lysosome Amine Content
dc.typeDissertation
dc.contributor.cmtememberAudus, Kenneth L.
dc.contributor.cmtememberMiddaugh, C. Russell
dc.contributor.cmtememberSiahaan, Teruna J.
dc.contributor.cmtememberOrr, James A
dc.thesis.degreeDisciplinePharmaceutical Chemistry
dc.thesis.degreeLevelPh.D.
kusw.oastatusna
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
kusw.bibid6857270
dc.rights.accessrightsopenAccess


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