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dc.contributor.authorWeidenbacher, Payton A.-B.
dc.contributor.authorSanyal, Mrinmoy
dc.contributor.authorFriedland, Natalia
dc.contributor.authorTang, Shaogeng
dc.contributor.authorArunachalam, Prabhu S.
dc.contributor.authorHu, Mengyun
dc.contributor.authorKumru, Ozan S.
dc.contributor.authorMorris, Mary Kate
dc.contributor.authorFontenot, Jane
dc.contributor.authorShirreff, Lisa
dc.contributor.authorDo, Jonathan
dc.contributor.authorCheng, Ya-Chen
dc.contributor.authorVasudevan, Gayathri
dc.contributor.authorFeinberg, Mark B.
dc.contributor.authorVillinger, Francois J.
dc.contributor.authorHanson, Carl
dc.contributor.authorJoshi, Sangeeta B.
dc.contributor.authorVolkin, David B.
dc.contributor.authorPulendra, Bali
dc.contributor.authorKim, Peter S.
dc.date.accessioned2023-05-30T19:40:23Z
dc.date.available2023-05-30T19:40:23Z
dc.date.issued2023-04-17
dc.identifier.citationWeidenbacher, P.AB., Sanyal, M., Friedland, N. et al. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nat Commun 14, 2149 (2023). https://doi.org/10.1038/s41467-023-37417-9en_US
dc.identifier.urihttps://hdl.handle.net/1808/34235
dc.description.abstractWhile the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. Following a booster ~one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. DCFHP-alum has potential as a once-yearly (or less frequent) booster vaccine, and as a primary vaccine for pediatric use including in infants.en_US
dc.publisherNature Researchen_US
dc.rights© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAntibodiesen_US
dc.subjectProtein vaccinesen_US
dc.subjectSARS-CoV-2en_US
dc.titleA ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primatesen_US
dc.typeArticleen_US
kusw.kuauthorKumru, Ozan S.
kusw.kuauthorJoshi, Sangeeta B.
kusw.kuauthorVolkin, David B.
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1038/s41467-023-37417-9en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7692-0458en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1365-4279en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0090-5689en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-4495-7501en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5010-7223en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8403-451Xen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-6517-4333en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-6503-4541en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC10110616en_US
dc.rights.accessrightsopenAccessen_US


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© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as: © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.