CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia

View/ Open
Issue Date
2022-10-04Author
Choi, Jiwoong
Chae, Kum Ju
Jin, Gong Yong
Lin, Ching-Long
Laroia, Archana T.
Hoffman, Eric A.
Lee, Chang Hyun
Publisher
Frontiers Media
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© 2022 Choi, Chae, Jin, Lin, Laroia, Hoffman and Lee. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY).
Metadata
Show full item recordAbstract
We applied quantitative CT image matching to assess the degree of motion in the idiopathic ILD such as usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Twenty-one normal subjects and 42 idiopathic ILD (31 UIP and 11 NSIP) patients were retrospectively included. Inspiratory and expiratory CT images, reviewed by two experienced radiologists, were used to compute displacement vectors at local lung regions matched by image registration. Normalized three-dimensional and two-dimensional (dorsal-basal) displacements were computed at a sub-acinar scale. Displacements, volume changes, and tissue fractions in the whole lung and the lobes were compared between normal, UIP, and NSIP subjects. The dorsal-basal displacement in lower lobes was smaller in UIP patients than in NSIP or normal subjects (p = 0.03, p = 0.04). UIP and NSIP were not differentiated by volume changes in the whole lung or upper and lower lobes (p = 0.53, p = 0.12, p = 0.97), whereas the lower lobe air volume change was smaller in both UIP and NSIP than normal subjects (p = 0.02, p = 0.001). Regional expiratory tissue fractions and displacements showed positive correlations in normal and UIP subjects but not in NSIP subjects. In summary, lung motionography quantified by image registration-based lower lobe dorsal-basal displacement may be used to assess the degree of motion, reflecting limited motion due to fibrosis in the ILD such as UIP and NSIP.
Collections
Citation
Choi J, Chae KJ, Jin GY, Lin C-L, Laroia AT, Hoffman EA and Lee CH (2022) CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia. Front. Physiol. 13:867473. doi: 10.3389/fphys.2022.867473
Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.