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Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines

dc.contributor.authorShcherbakov, Stanislav S.
dc.contributor.authorMagometov, Artyom Yu.
dc.contributor.authorShcherbakova, Viktoriia Yu.
dc.contributor.authorAksenov, Alexander V.
dc.contributor.authorDomenyuk, Dmitriy A.
dc.contributor.authorZelensky, Vladimir A.
dc.contributor.authorRubin, Michael
dc.date.accessioned2022-09-20T14:10:07Z
dc.date.available2022-09-20T14:10:07Z
dc.date.issued2020-03-10
dc.identifier.citationShcherbakov, S.S.; et al. Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines. RSC Adv., 2020,10, 10315-10321. https://doi.org/10.1039/D0RA01335Hen_US
dc.identifier.urihttp://hdl.handle.net/1808/33538
dc.description.abstractA new synthetic protocol for preparation of medicinally important 4-aryl-5-alkynylpyrimidines is described. The featured approach involves a sequence of chemo- and regioselective Brønsted acid-catalyzed electrophilic alkylation of arenes with 5-bromopyrimidine, followed by oxidative re-aromatization of the formed dihydropyrimidine ring. Finally, palladium-catalyzed Sonogashira cross-coupling reaction provided an end-game strategy.en_US
dc.publisherRoyal Society of Chemistryen_US
dc.rights© The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en_US
dc.titleElectrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidinesen_US
dc.typeArticleen_US
kusw.kuauthorRubin, Michael
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1039/D0RA01335Hen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-6644-9949en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1668-9311en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccessen_US


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© The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Except where otherwise noted, this item's license is described as: © The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.