Flavin Metallaphotoredox Catalysis: Synergistic Synthesis in Water

Chilamari, Maheshwerreddy; Immel, Jacob R.; Chen, Pei-Hsuan; Alghafli, Bayan M.; Bloom, Steven

dc.contributor.author	Chilamari, Maheshwerreddy
dc.contributor.author	Immel, Jacob R.
dc.contributor.author	Chen, Pei-Hsuan
dc.contributor.author	Alghafli, Bayan M.
dc.contributor.author	Bloom, Steven
dc.date.accessioned	2022-08-15T18:14:09Z
dc.date.available	2022-08-15T18:14:09Z
dc.date.issued	2022-03-22
dc.identifier.citation	Chilamari, M., Immel, J. R., Chen, P. H., Alghafli, B. M., & Bloom, S. (2022). Flavin Metallaphotoredox Catalysis: Synergistic Synthesis in Water. ACS catalysis, 12(7), 4175–4181. https://doi.org/10.1021/acscatal.2c00773	en_US
dc.identifier.uri	http://hdl.handle.net/1808/33206
dc.description	This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acscatal.2c00773.	en_US
dc.description.abstract	Combining a transition metal with a photocatalyst can drive modern synthetic chemistry. For transformations performed in water, this concept has been largely unexplored. We report the successful merger of a biocompatible flavin photocatalyst with a palladium catalyst to build isotopically enriched peptidomimetics, to mediate conjugate addition and C–H functionalization reactions, and to assemble unprotected proteinogenic and nonproteinogenic peptides, in water. We detail the important role of the ligand and the palladium oxidation state for controlling product selectivity when constructing synthetic peptides.	en_US
dc.publisher	American Chemical Society	en_US
dc.rights	Copyright © 2022 American Chemical Society	en_US
dc.subject	Metallaphotoredox	en_US
dc.subject	Flavin	en_US
dc.subject	Boronic acids	en_US
dc.subject	Biocompatible	en_US
dc.subject	Isotopes	en_US
dc.subject	Peptidomimetics	en_US
dc.title	Flavin Metallaphotoredox Catalysis: Synergistic Synthesis in Water	en_US
dc.type	Article	en_US
kusw.kuauthor	Chilamari, Maheshwerreddy
kusw.kuauthor	Immel, Jacob R.
kusw.kuauthor	Chen, Pei-Hsuan
kusw.kuauthor	Alghafli, Bayan M.
kusw.kuauthor	Bloom, Steven
kusw.kudepartment	Medicinal Chemistry	en_US
dc.identifier.doi	10.1021/acscatal.2c00773	en_US
dc.identifier.orcid	https://orcid.org/0000-0002-4205-4459	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	35865831	en_US
dc.rights.accessrights	embargoedAccess	en_US

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