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    Flavin Metallaphotoredox Catalysis: Synergistic Synthesis in Water

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    Available after: 03/22/2023 (1.249Mb)
    Issue Date
    2022-03-22
    Author
    Chilamari, Maheshwerreddy
    Immel, Jacob R.
    Chen, Pei-Hsuan
    Alghafli, Bayan M.
    Bloom, Steven
    Publisher
    American Chemical Society
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    Copyright © 2022 American Chemical Society
    Metadata
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    Abstract
    Combining a transition metal with a photocatalyst can drive modern synthetic chemistry. For transformations performed in water, this concept has been largely unexplored. We report the successful merger of a biocompatible flavin photocatalyst with a palladium catalyst to build isotopically enriched peptidomimetics, to mediate conjugate addition and C–H functionalization reactions, and to assemble unprotected proteinogenic and nonproteinogenic peptides, in water. We detail the important role of the ligand and the palladium oxidation state for controlling product selectivity when constructing synthetic peptides.
    Description
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acscatal.2c00773.
    URI
    http://hdl.handle.net/1808/33206
    DOI
    https://doi.org/10.1021/acscatal.2c00773
    Collections
    • Medicinal Chemistry Scholarly Works [255]
    Citation
    Chilamari, M., Immel, J. R., Chen, P. H., Alghafli, B. M., & Bloom, S. (2022). Flavin Metallaphotoredox Catalysis: Synergistic Synthesis in Water. ACS catalysis, 12(7), 4175–4181. https://doi.org/10.1021/acscatal.2c00773

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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