dc.contributor.author | Aksenov, Nicolai A. | |
dc.contributor.author | Aksenov, Alexander V. | |
dc.contributor.author | Kornienko, Alexander | |
dc.contributor.author | De Carvalho, Annelise | |
dc.contributor.author | Mathieu, Véronique | |
dc.contributor.author | Aksenov, Dmitrii A. | |
dc.contributor.author | Ovcharov, Sergei N. | |
dc.contributor.author | Griaznov, Georgii D. | |
dc.contributor.author | Rubin, Michael | |
dc.date.accessioned | 2022-07-12T18:21:28Z | |
dc.date.available | 2022-07-12T18:21:28Z | |
dc.date.issued | 2018-11-01 | |
dc.identifier.citation | Aksenov NA, Aksenov AV, Kornienko A, De Carvalho A, Mathieu V, Aksenov DA, Ovcharov SN, Griaznov GD, Rubin M. A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities. RSC Adv. 2018 Nov 1;8(64):36980-36986. doi: 10.1039/c8ra08155g. PMID: 35558925; PMCID: PMC9089289. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/32831 | |
dc.description.abstract | A second generation polyphosphoric acid-mediated one-pot three-component synthesis of indoloquinoline scaffold is developed. This improved version of the process involves electrophilically activated nitroalkanes for the installation of strategic C–C and C–N bonds and ring C assembly. This modification allows the elimination of unnecessary solvent change operations and all steps are carried out in a true, uninterrupted one-pot manner. A further improvement involves the possibility to install an ortho-amino group in situ. A synthetic application of this method is showcased by the concise synthesis of an isocryptolepine alkaloid and its synthetic analogs with potent anticancer activities. | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. © The Royal Society of Chemistry 2018. | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | en_US |
dc.title | A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Rubin, Michael | |
kusw.kudepartment | Chemistry | en_US |
dc.identifier.doi | 10.1039/c8ra08155g | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0002-7125-9066 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0002-6644-9949 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0003-2041-7367 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0002-1668-9311 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC35558925 | en_US |
dc.rights.accessrights | openAccess | en_US |