A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities

Aksenov, Nicolai A.; Aksenov, Alexander V.; Kornienko, Alexander; De Carvalho, Annelise; Mathieu, Véronique; Aksenov, Dmitrii A.; Ovcharov, Sergei N.; Griaznov, Georgii D.; Rubin, Michael

dc.contributor.author	Aksenov, Nicolai A.
dc.contributor.author	Aksenov, Alexander V.
dc.contributor.author	Kornienko, Alexander
dc.contributor.author	De Carvalho, Annelise
dc.contributor.author	Mathieu, Véronique
dc.contributor.author	Aksenov, Dmitrii A.
dc.contributor.author	Ovcharov, Sergei N.
dc.contributor.author	Griaznov, Georgii D.
dc.contributor.author	Rubin, Michael
dc.date.accessioned	2022-07-12T18:21:28Z
dc.date.available	2022-07-12T18:21:28Z
dc.date.issued	2018-11-01
dc.identifier.citation	Aksenov NA, Aksenov AV, Kornienko A, De Carvalho A, Mathieu V, Aksenov DA, Ovcharov SN, Griaznov GD, Rubin M. A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities. RSC Adv. 2018 Nov 1;8(64):36980-36986. doi: 10.1039/c8ra08155g. PMID: 35558925; PMCID: PMC9089289.	en_US
dc.identifier.uri	http://hdl.handle.net/1808/32831
dc.description.abstract	A second generation polyphosphoric acid-mediated one-pot three-component synthesis of indoloquinoline scaffold is developed. This improved version of the process involves electrophilically activated nitroalkanes for the installation of strategic C–C and C–N bonds and ring C assembly. This modification allows the elimination of unnecessary solvent change operations and all steps are carried out in a true, uninterrupted one-pot manner. A further improvement involves the possibility to install an ortho-amino group in situ. A synthetic application of this method is showcased by the concise synthesis of an isocryptolepine alkaloid and its synthetic analogs with potent anticancer activities.	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. © The Royal Society of Chemistry 2018.	en_US
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	en_US
dc.title	A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities	en_US
dc.type	Article	en_US
kusw.kuauthor	Rubin, Michael
kusw.kudepartment	Chemistry	en_US
dc.identifier.doi	10.1039/c8ra08155g	en_US
dc.identifier.orcid	https://orcid.org/ 0000-0002-7125-9066	en_US
dc.identifier.orcid	https://orcid.org/ 0000-0002-6644-9949	en_US
dc.identifier.orcid	https://orcid.org/ 0000-0003-2041-7367	en_US
dc.identifier.orcid	https://orcid.org/ 0000-0002-1668-9311	en_US
kusw.oaversion	Scholarly/refereed, publisher version	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC35558925	en_US
dc.rights.accessrights	openAccess	en_US

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