Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles

Thumbnail
View/Open
Issue Date
2022-04-15
Author
Aksenov, Nicolai A.
Aksenov, Alexander V.
Prityko, Lidiya A.
Aksenov, Dmitrii A.
Aksenova, Daria S.
Nobi, Mezvah A.
Rubin, Michael
Publisher
American Chemical Society
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© 2022 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND).
Metadata
Show full item record
Abstract
A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the aniline moiety. Overall, this modification allowed for the improvement of yields and expansion of the reaction scope.
URI
http://hdl.handle.net/1808/32826
DOI
https://doi.org/10.1021/acsomega.2c01238
Collections
Citation
Aksenov NA, Aksenov AV, Prityko LA, Aksenov DA, Aksenova DS, Nobi MA, Rubin M. Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles. ACS Omega. 2022 Apr 15;7(16):14345-14356. doi: 10.1021/acsomega.2c01238. PMID: 35573208; PMCID: PMC9089741.

Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.

© 2022 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND).
Except where otherwise noted, this item's license is described as: © 2022 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND).