dc.contributor.author | Winston, Tackla S. | |
dc.contributor.author | Chen, Chao | |
dc.contributor.author | Suddhapas, Kantaphon | |
dc.contributor.author | Tarris, Bearett A. | |
dc.contributor.author | Elattar, Saif | |
dc.contributor.author | Sun, Shiyang | |
dc.contributor.author | Zhang, Teng | |
dc.contributor.author | Ma, Zhen | |
dc.date.accessioned | 2022-05-02T16:22:32Z | |
dc.date.available | 2022-05-02T16:22:32Z | |
dc.date.issued | 2022-02-18 | |
dc.identifier.citation | Winston TS, Chen C, Suddhapas K, Tarris BA, Elattar S, Sun S, Zhang T and Ma Z (2022) Controlling Mesenchyme Tissue Remodeling via Spatial Arrangement of Mechanical Constraints. Front. Bioeng. Biotechnol. 10:833595. doi: 10.3389/fbioe.2022.833595 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/32735 | |
dc.description.abstract | Tissue morphogenetic remodeling plays an important role in tissue repair and homeostasis and is often governed by mechanical stresses. In this study, we integrated an in vitro mesenchymal tissue experimental model with a volumetric contraction-based computational model to investigate how geometrical designs of tissue mechanical constraints affect the tissue remodeling processes. Both experimental data and simulation results verified that the standing posts resisted the bulk contraction of the tissues, leading to tissue thinning around the posts as gap extension and inward remodeling at the edges as tissue compaction. We changed the geometrical designs for the engineered mesenchymal tissues with different shapes of posts arrangements (triangle vs. square), different side lengths (6 mm vs. 8 mm), and insertion of a center post. Both experimental data and simulation results showed similar trends of tissue morphological changes of significant increase of gap extension and deflection compaction with larger tissues. Additionally, insertion of center post changed the mechanical stress distribution within the tissues and stabilized the tissue remodeling. This experimental-computational integrated model can be considered as a promising initiative for future mechanistic understanding of the relationship between mechanical design and tissue remodeling, which could possibly provide design rationale for tissue stability and manufacturing. | en_US |
dc.publisher | Frontiers Media | en_US |
dc.rights | © 2022 Winston, Chen, Suddhapas, Tarris, Elattar, Sun, Zhang and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Tissue remodeling | en_US |
dc.subject | Tissue mechanics | en_US |
dc.subject | Human induced pluripotent stem cell (hiPSC) | en_US |
dc.subject | Finite element analyses | en_US |
dc.subject | Mesenchymal stem cells | en_US |
dc.subject | Tissue morphogenesis | en_US |
dc.title | Controlling Mesenchyme Tissue Remodeling via Spatial Arrangement of Mechanical Constraints | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Elattar, Saif | |
kusw.kudepartment | Chemical and Petroleum Engineering | en_US |
dc.identifier.doi | 10.3389/fbioe.2022.833595 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC8896258 | en_US |
dc.rights.accessrights | openAccess | en_US |