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    Microfluidic Analysis of Exosomal Biomarkers towards Liquid Biopsy Diagnosis of Alzheimer's Disease

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    Available after: 2022-08-31 (1.355Mb)
    Issue Date
    2020-01-01
    Author
    Zhang, Yaohua
    Publisher
    University of Kansas
    Format
    55 pages
    Type
    Thesis
    Degree Level
    M.S.
    Discipline
    Bioengineering
    Rights
    Copyright held by the author.
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    Abstract
    Alzheimer's Disease has posed a critical challenge to the global health system. Although no cure is currently available, early diagnosis is beneficial to both the health system and patients. To improve early diagnosis, a microfluidic platform is proposed to capture and detect neuronal exosomes. In this study, the microfluidic platform was first optimized and evaluated by a commercialized ELISA kit, and neuronal cell marker and neuronal exosomes were captured and analyzed on-chip by sandwich ELISA. The microchip achieved high sensitivity for both protein and exosome, which reaches 10pg/ml and 106 level respectively. Overall, this study illustrates the potentiality of the proposed microfluidic platform, which will be further improved to be applied for AD early diagnosis study.
    URI
    http://hdl.handle.net/1808/32606
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    • Theses [3768]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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