Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes

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Issue Date
2020-11-26
Author
Aksenov, Dmitrii A.
Arutiunov, Nikolai A.
Maliuga, Vladimir V.
Aksenov, Alexander V.
Rubin, Michael
Publisher
Beilstein-Institut
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© 2020 Aksenov et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc)
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Abstract
Imidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.
URI
http://hdl.handle.net/1808/32407
DOI
https://doi.org/10.3762/bjoc.16.239
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Citation
Aksenov, D. A.; Arutiunov, N. A.; Maliuga, V. V.; Aksenov, A. V.; Rubin, M. Beilstein J. Org. Chem. 2020, 16, 2903–2910. doi:10.3762/bjoc.16.239

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© 2020 Aksenov et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc)
Except where otherwise noted, this item's license is described as: © 2020 Aksenov et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc)