dc.contributor.author | Muthuramalingam, Meenakumari | |
dc.contributor.author | Whittier, Sean K. | |
dc.contributor.author | Picking, Wendy L. | |
dc.contributor.author | Picking, William D. | |
dc.date.accessioned | 2022-01-07T20:18:18Z | |
dc.date.available | 2022-01-07T20:18:18Z | |
dc.date.issued | 2021-02-22 | |
dc.identifier.citation | Muthuramalingam, M.; Whittier, S.K.; Picking, W.L.; Picking, W.D. The Shigella Type III Secretion System: An Overview from Top to Bottom. Microorganisms 2021, 9, 451. https://doi.org/10.3390/microorganisms9020451 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/32368 | |
dc.description.abstract | Shigella comprises four species of human-restricted pathogens causing bacillary dysentery. While Shigella possesses multiple genetic loci contributing to virulence, a type III secretion system (T3SS) is its primary virulence factor. The Shigella T3SS nanomachine consists of four major assemblies: the cytoplasmic sorting platform; the envelope-spanning core/basal body; an exposed needle; and a needle-associated tip complex with associated translocon that is inserted into host cell membranes. The initial subversion of host cell activities is carried out by the effector functions of the invasion plasmid antigen (Ipa) translocator proteins, with the cell ultimately being controlled by dedicated effector proteins that are injected into the host cytoplasm though the translocon. Much of the information now available on the T3SS injectisome has been accumulated through collective studies on the T3SS from three systems, those of Shigella flexneri, Salmonella typhimurium and Yersinia enterocolitica/Yersinia pestis. In this review, we will touch upon the important features of the T3SS injectisome that have come to light because of research in the Shigella and closely related systems. We will also briefly highlight some of the strategies being considered to target the Shigella T3SS for disease prevention. | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Shigella | en_US |
dc.subject | Type III secretion system | en_US |
dc.subject | T3SS | en_US |
dc.subject | Injectisome | en_US |
dc.subject | Tip complex | en_US |
dc.subject | Translocator | en_US |
dc.subject | Sorting platform | en_US |
dc.title | The Shigella Type III Secretion System: An Overview from Top to Bottom | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Muthuramalingam, Meenakumari | |
kusw.kuauthor | Whittier, Sean K. | |
kusw.kuauthor | Picking, Wendy L. | |
kusw.kuauthor | Picking, William D. | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.3390/microorganisms9020451 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0001-9852-7545 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC7926512 | en_US |
dc.rights.accessrights | openAccess | en_US |