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Dataset of why inclusion matters for Alzheimer's disease biomarker discovery in plasma
dc.contributor.author | Khan, Mostafa J. | |
dc.contributor.author | Desaire, Heather | |
dc.contributor.author | Lopez, Oscar L. | |
dc.contributor.author | Kamboh, M. Ilyas | |
dc.contributor.author | Robinson, Renã A.S. | |
dc.date.accessioned | 2022-01-06T18:42:54Z | |
dc.date.available | 2022-01-06T18:42:54Z | |
dc.date.issued | 2021-04 | |
dc.identifier.citation | Khan, M. J., Desaire, H., Lopez, O. L., Ilyas Kamboh, M., & Robinson, R. (2021). Dataset of why inclusion matters for Alzheimer's disease biomarker discovery in plasma. Data in brief, 35, 106923. https://doi.org/10.1016/j.dib.2021.106923 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/32352 | |
dc.description.abstract | Here we present a plasma proteomics dataset that was generated to understand the importance of self-reported race for biomarker discovery in Alzheimer's disease. This dataset is related to the article “Why inclusion matters for Alzheimer's disease biomarker discovery in plasma” [1]. Plasma samples were obtained from clinically diagnosed Alzheimer's disease and cognitively normal adults of African American/Black and non-Hispanic White racial and ethnic backgrounds. Plasma was immunodepleted, digested, and isobarically tagged with commercial reagents. Tagged peptides were fractionated using high pH fractionation and resulting fractions analysed by liquid chromatography – mass spectrometry (LC-MS/MS & MS3) analysis on an Orbitrap Fusion Lumos mass spectrometer. The resulting data was processed using Proteome Discoverer to produce a list of identified proteins with corresponding tandem mass tag (TMT) intensity information. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Plasma | en_US |
dc.subject | Proteomics | en_US |
dc.subject | Biomarker | en_US |
dc.subject | African American | en_US |
dc.subject | Black | en_US |
dc.subject | Disparities | en_US |
dc.title | Dataset of why inclusion matters for Alzheimer's disease biomarker discovery in plasma | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Desaire, Heather | |
kusw.kudepartment | Chemistry | en_US |
dc.identifier.doi | 10.1016/j.dib.2021.106923 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC7988280 | en_US |
dc.rights.accessrights | openAccess | en_US |