Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome
dc.contributor.author | Mariscal, Michael G. | |
dc.contributor.author | Berry-Kravis, Elizabeth | |
dc.contributor.author | Buxbaum, Joseph D. | |
dc.contributor.author | Ethridge, Lauren E. | |
dc.contributor.author | Filip-Dhima, Rajna | |
dc.contributor.author | Foss-Feig, Jennifer H. | |
dc.contributor.author | Kolevzon, Alexander | |
dc.contributor.author | Modi, Meera E. | |
dc.contributor.author | Mosconi, Matthew W. | |
dc.contributor.author | Nelson, Charles A. | |
dc.contributor.author | Powell, Craig M. | |
dc.contributor.author | Siper, Paige M. | |
dc.contributor.author | Soorya, Latha | |
dc.contributor.author | Thaliath, Andrew | |
dc.contributor.author | Thurm, Audrey | |
dc.contributor.author | Zhang, Bo | |
dc.contributor.author | Sahin, Mustafa | |
dc.contributor.author | Levin, April R. | |
dc.date.accessioned | 2021-12-22T21:30:38Z | |
dc.date.available | 2021-12-22T21:30:38Z | |
dc.date.issued | 2021-04-28 | |
dc.identifier.citation | Mariscal, M. G., Berry-Kravis, E., Buxbaum, J. D., Ethridge, L. E., Filip-Dhima, R., Foss-Feig, J. H., Kolevzon, A., Modi, M. E., Mosconi, M. W., Nelson, C. A., Powell, C. M., Siper, P. M., Soorya, L., Thaliath, A., Thurm, A., Zhang, B., Sahin, M., Levin, A. R., & Developmental Synaptopathies Consortium (2021). Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome. Molecular autism, 12(1), 29. https://doi.org/10.1186/s13229-020-00411-9 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/32309 | |
dc.description.abstract | Background Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neurodevelopmental challenges. Electroencephalography (EEG) can provide a window into network-level function in PMS.Methods Here, we analyze EEG data collected across multiple sites in individuals with PMS (n = 26) and typically developing individuals (n = 15). We quantify oscillatory power, alpha-gamma phase-amplitude coupling strength, and phase bias, a measure of the phase of cross frequency coupling thought to reflect the balance of feedforward (bottom-up) and feedback (top-down) activity.Results We find individuals with PMS display increased alpha-gamma phase bias (U = 3.841, p < 0.0005), predominantly over posterior electrodes. Most individuals with PMS demonstrate positive overall phase bias while most typically developing individuals demonstrate negative overall phase bias. Among individuals with PMS, strength of alpha-gamma phase-amplitude coupling was associated with Sameness, Ritualistic, and Compulsive behaviors as measured by the Repetitive Behavior Scales-Revised (Beta = 0.545, p = 0.011).Conclusions Increased phase bias suggests potential circuit-level mechanisms underlying phenotype in PMS, offering opportunities for back-translation of findings into animal models and targeting in clinical trials. | en_US |
dc.publisher | BMC | en_US |
dc.rights | © The Author(s) 2021. This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Phelan-McDermid syndrome | en_US |
dc.subject | EEG | en_US |
dc.subject | Power | en_US |
dc.subject | Cross-frequency coupling | en_US |
dc.subject | Phase bias | en_US |
dc.title | Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Mosconi, Matthew W. | |
kusw.kudepartment | Schiefelbusch Institute for Life Span Studies | en_US |
dc.identifier.doi | 10.1186/s13229-020-00411-9 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0003-4192-4720 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC8082621 | en_US |
dc.rights.accessrights | openAccess | en_US |
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