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dc.contributor.authorMariscal, Michael G.
dc.contributor.authorBerry-Kravis, Elizabeth
dc.contributor.authorBuxbaum, Joseph D.
dc.contributor.authorEthridge, Lauren E.
dc.contributor.authorFilip-Dhima, Rajna
dc.contributor.authorFoss-Feig, Jennifer H.
dc.contributor.authorKolevzon, Alexander
dc.contributor.authorModi, Meera E.
dc.contributor.authorMosconi, Matthew W.
dc.contributor.authorNelson, Charles A.
dc.contributor.authorPowell, Craig M.
dc.contributor.authorSiper, Paige M.
dc.contributor.authorSoorya, Latha
dc.contributor.authorThaliath, Andrew
dc.contributor.authorThurm, Audrey
dc.contributor.authorZhang, Bo
dc.contributor.authorSahin, Mustafa
dc.contributor.authorLevin, April R.
dc.identifier.citationMariscal, M. G., Berry-Kravis, E., Buxbaum, J. D., Ethridge, L. E., Filip-Dhima, R., Foss-Feig, J. H., Kolevzon, A., Modi, M. E., Mosconi, M. W., Nelson, C. A., Powell, C. M., Siper, P. M., Soorya, L., Thaliath, A., Thurm, A., Zhang, B., Sahin, M., Levin, A. R., & Developmental Synaptopathies Consortium (2021). Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome. Molecular autism, 12(1), 29.
dc.description.abstractBackground Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neurodevelopmental challenges. Electroencephalography (EEG) can provide a window into network-level function in PMS.

Methods Here, we analyze EEG data collected across multiple sites in individuals with PMS (n = 26) and typically developing individuals (n = 15). We quantify oscillatory power, alpha-gamma phase-amplitude coupling strength, and phase bias, a measure of the phase of cross frequency coupling thought to reflect the balance of feedforward (bottom-up) and feedback (top-down) activity.

Results We find individuals with PMS display increased alpha-gamma phase bias (U = 3.841, p < 0.0005), predominantly over posterior electrodes. Most individuals with PMS demonstrate positive overall phase bias while most typically developing individuals demonstrate negative overall phase bias. Among individuals with PMS, strength of alpha-gamma phase-amplitude coupling was associated with Sameness, Ritualistic, and Compulsive behaviors as measured by the Repetitive Behavior Scales-Revised (Beta = 0.545, p = 0.011).

Conclusions Increased phase bias suggests potential circuit-level mechanisms underlying phenotype in PMS, offering opportunities for back-translation of findings into animal models and targeting in clinical trials.
dc.rights© The Author(s) 2021. This work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.subjectPhelan-McDermid syndromeen_US
dc.subjectCross-frequency couplingen_US
dc.subjectPhase biasen_US
dc.titleShifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndromeen_US
kusw.kuauthorMosconi, Matthew W.
kusw.kudepartmentSchiefelbusch Institute for Life Span Studiesen_US
kusw.oanotesPer Sherpa Romeo 12/22/2021:

Molecular Autism [Open panel below]Publication Information TitleMolecular Autism [English] ISSNsElectronic: 2040-2392 URL PublishersBMC [Commercial Publisher] DOAJ Listing Requires APCYes [Data provided by DOAJ] [Open panel below]Publisher Policy Open Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view.

Published Version NoneCC BYPMC Any Website, Journal Website, +3 OA PublishingThis pathway includes Open Access publishing EmbargoNo Embargo LicenceCC BY Copyright OwnerAuthors Publisher Deposit PubMed Central Europe PMC Location Any Website Author's Homepage Institutional Repository Named Repository (PubMed Central) Journal Website Conditions Copy of License must accompany any deposit. Published source must be acknowledged Must link to publisher version with DOI
dc.identifier.orcid 0000-0003-4192-4720en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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© The Author(s) 2021. This work is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as: © The Author(s) 2021. This work is licensed under a Creative Commons Attribution 4.0 International License.