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dc.contributor.authorTownsend, Jakob M.
dc.contributor.authorDennis, S. Connor
dc.contributor.authorWhitlow, Jonathan
dc.contributor.authorFeng, Yi
dc.contributor.authorWang, Jinxi
dc.contributor.authorAndrews, Brian
dc.contributor.authorNudo, Randolph J.
dc.contributor.authorDetamore, Michael S.
dc.contributor.authorBerkland, Cory J.
dc.identifier.citationTownsend, J. M., Dennis, S. C., Whitlow, J., Feng, Y., Wang, J., Andrews, B., … Berkland, C. J. (2017). Colloidal Gels with Extracellular Matrix Particles and Growth Factors for Bone Regeneration in Critical Size Rat Calvarial Defects. The AAPS journal, 19(3), 703–711. doi:10.1208/s12248-017-0045-0en_US
dc.description.abstractColloidal gels encapsulating natural materials and exhibiting paste-like properties for placement are promising for filling complex geometries in craniofacial bone regeneration applications. Colloidal materials have demonstrated modest clinical outcomes as bone substitutes in orthopedic applications, but limited success in craniofacial applications. As such, development of a novel colloidal gel will fill a void in commercially available products for use in craniofacial reconstruction. One likely application for this technology is cranial reconstruction. Currently, traumatic brain injury (TBI) is often treated with a hemi-craniectomy, a procedure in which half the cranium is removed to allow the injured brain to swell and herniate beyond the enclosed cranial vault. The use of colloidal gels would allow for the design of a pliable material capable of expansion during brain swelling and facilitate cranial bone regeneration alleviating the need for a second surgery to replace the previously removed hemi-cranium. In the current study, colloidal nanoparticles of hydroxyapatite (HAp), demineralized bone matrix (DBM), and decellularized cartilage (DCC) were combined with hyaluronic acid (HA) to form colloidal gels with desirable rheological properties (τy ≥ 100 Pa). BMP-2 and VEGF growth factors were included to assess extracellular matrix (ECM) contribution of DBM and DCC. The HA-HAp (BMP-2) and HA-HAp-DCC group had 89 and 82% higher bone regeneration compared to the sham group, respectively (p < 0.01). Material retention issues observed may be alleviated by implementing chemical crosslinking. Overall, DCC may be a promising material for bone regeneration in general, and colloidal gels may hold significant potential in craniofacial applications.en_US
dc.rights© 2017, Springer Natureen_US
dc.subjectColloidal gelen_US
dc.subjectDecellularized cartilageen_US
dc.subjectExtracellular matrixen_US
dc.subjectHyaluronic aciden_US
dc.titleColloidal Gels with Extracellular Matrix Particles and Growth Factors for Bone Regeneration in Critical Size Rat Calvarial Defectsen_US
kusw.kuauthorDennis, S. Connor
kusw.kuauthorWhitlow, Jonathan
kusw.kuauthorBerkland, Cory J.
kusw.kudepartmentBioengineering Programen_US
kusw.kudepartmentDepartment of Pharmaceutical Chemistryen_US
kusw.oanotesPer SHERPA/RoMEO 02/10/2020: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions:

Now published by Springer (1st Jan 2007) Authors own final version only can be archived Publisher's version/PDF cannot be used On author's personal website On institutional repository or funders designated website/repository after 12 months Published source must be acknowledged Must link to publisher version Set phrase to accompany link to published version: The original publication is available at Articles in some journals can be made Open Access on payment of additional charge NIH Authors can deposit in PubMed Central for public release after 12 month embargo
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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