The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases

Jiang, Beichen; Moskovitz, Jackob

dc.contributor.author	Jiang, Beichen
dc.contributor.author	Moskovitz, Jackob
dc.date.accessioned	2020-12-02T15:45:45Z
dc.date.available	2020-12-02T15:45:45Z
dc.date.issued	2018-09-18
dc.identifier.citation	Jiang, B., & Moskovitz, J. (2018). The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases. Antioxidants (Basel, Switzerland), 7(9), 122. https://doi.org/10.3390/antiox7090122	en_US
dc.identifier.uri	http://hdl.handle.net/1808/30953
dc.description	This work is licensed under a Creative Commons Attribution 4.0 International License.	en_US
dc.description.abstract	This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/organism is the MSRA knockout. The deficiency of MSRA in this mouse model provides hints and evidence for this enzyme function in health and disease. Accordingly, the potential involvement of MSRA in the processes leading to neurodegenerative diseases, neurological disorders, cystic fibrosis, cancer, and hearing loss will be deliberated and evaluated.	en_US
dc.description.sponsorship	Hedwig Miller Fund for Aging Research	en_US
dc.publisher	MDPI	en_US
dc.rights	© 2018 by the authors. Licensee MDPI, Basel, Switzerland.	en_US
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en_US
dc.subject	Methionine sulfoxide reductase	en_US
dc.subject	Methionine oxidation	en_US
dc.subject	Oxidative stress	en_US
dc.title	The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases	en_US
dc.type	Article	en_US
kusw.kuauthor	Jiang, Beichen
kusw.kuauthor	Moskovitz, Jackob
kusw.kudepartment	Pharmacology and Toxicology	en_US
dc.identifier.doi	10.3390/antiox7090122	en_US
dc.identifier.orcid	https://orcid.org/0000-0001-7694-8074	en_US
kusw.oaversion	Scholarly/refereed, publisher version	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC6162418	en_US
dc.rights.accessrights	openAccess	en_US

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