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Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol

dc.contributor.authorMotiwala, Hashim F.
dc.contributor.authorYin, Qin
dc.contributor.authorAubé, Jeffrey
dc.date.accessioned2020-12-01T16:07:12Z
dc.date.available2020-12-01T16:07:12Z
dc.date.issued2015-12-29
dc.identifier.citationMotiwala, H. F., Yin, Q., & Aubé, J. (2015). Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol. Molecules (Basel, Switzerland), 21(1), E45. https://doi.org/10.3390/molecules21010045en_US
dc.identifier.urihttp://hdl.handle.net/1808/30938
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractThe Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up.en_US
dc.description.sponsorshipUniversity of Kansasen_US
dc.publisherMDPIen_US
dc.rights© 2015 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectSchmidt reactionen_US
dc.subjectAldehydesen_US
dc.subjectNitrilesen_US
dc.subjectHFIPen_US
dc.titleImproved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanolen_US
dc.typeArticleen_US
kusw.kuauthorMotiwala, Hashim F.
kusw.kuauthorYin, Qin
kusw.kuauthorAubé, Jeffrey
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.3390/molecules21010045en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1049-5767en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6273554en_US
dc.rights.accessrightsopenAccessen_US


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© 2015 by the authors. Licensee MDPI, Basel, Switzerland.
Except where otherwise noted, this item's license is described as: © 2015 by the authors. Licensee MDPI, Basel, Switzerland.