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Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol
| dc.contributor.author | Motiwala, Hashim F. | |
| dc.contributor.author | Yin, Qin | |
| dc.contributor.author | Aubé, Jeffrey | |
| dc.date.accessioned | 2020-12-01T16:07:12Z | |
| dc.date.available | 2020-12-01T16:07:12Z | |
| dc.date.issued | 2015-12-29 | |
| dc.identifier.citation | Motiwala, H. F., Yin, Q., & Aubé, J. (2015). Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol. Molecules (Basel, Switzerland), 21(1), E45. https://doi.org/10.3390/molecules21010045 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/30938 | |
| dc.description | This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
| dc.description.abstract | The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up. | en_US |
| dc.description.sponsorship | University of Kansas | en_US |
| dc.publisher | MDPI | en_US |
| dc.rights | © 2015 by the authors. Licensee MDPI, Basel, Switzerland. | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.subject | Schmidt reaction | en_US |
| dc.subject | Aldehydes | en_US |
| dc.subject | Nitriles | en_US |
| dc.subject | HFIP | en_US |
| dc.title | Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Motiwala, Hashim F. | |
| kusw.kuauthor | Yin, Qin | |
| kusw.kuauthor | Aubé, Jeffrey | |
| kusw.kudepartment | Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.3390/molecules21010045 | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-1049-5767 | en_US |
| kusw.oaversion | Scholarly/refereed, publisher version | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC6273554 | en_US |
| dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: © 2015 by the authors. Licensee MDPI, Basel, Switzerland.
