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dc.contributor.authorWang, Zheng
dc.contributor.authorWang, Yan
dc.contributor.authorSweeney, John A.
dc.contributor.authorGong, Qiyong
dc.contributor.authorLui, Su
dc.contributor.authorMosconi, Matthew W.
dc.identifier.citationWang, Z., Wang, Y., Sweeney, J. A., Gong, Q., Lui, S., & Mosconi, M. W. (2019). Resting-State Brain Network Dysfunctions Associated With Visuomotor Impairments in Autism Spectrum Disorder. Frontiers in integrative neuroscience, 13, 17.
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractBackground: Individuals with autism spectrum disorder (ASD) show elevated levels of motor variability that are associated with clinical outcomes. Cortical–cerebellar networks involved in visuomotor control have been implicated in postmortem and anatomical imaging studies of ASD. However, the extent to which these networks show intrinsic functional alterations in patients, and the relationship between intrinsic functional properties of cortical–cerebellar networks and visuomotor impairments in ASD have not yet been clarified.

Methods: We examined the amplitude of low-frequency fluctuation (ALFF) of cortical and cerebellar brain regions during resting-state functional MRI (rs-fMRI) in 23 individuals with ASD and 16 typically developing (TD) controls. Regions of interest (ROIs) with ALFF values significantly associated with motor variability were identified for for patients and controls respectively, and their functional connectivity (FC) to each other and to the rest of the brain was examined.

Results: For TD controls, greater ALFF in bilateral cerebellar crus I, left superior temporal gyrus, left inferior frontal gyrus, right supramarginal gyrus, and left angular gyrus each were associated with greater visuomotor variability. Greater ALFF in cerebellar lobule VIII was associated with less visuomotor variability. For individuals with ASD, greater ALFF in right calcarine cortex, right middle temporal gyrus (including MT/V5), left Heschl's gyrus, left post-central gyrus, right pre-central gyrus, and left precuneus was related to greater visuomotor variability. Greater ALFF in cerebellar vermis VI was associated with less visuomotor variability. Individuals with ASD and TD controls did not show differences in ALFF for any of these ROIs. Individuals with ASD showed greater posterior cerebellar connectivity with occipital and parietal cortices relative to TD controls, and reduced FC within cerebellum and between lateral cerebellum and pre-frontal and other regions of association cortex.

Conclusion: Together, these findings suggest that increased resting oscillations within visuomotor networks in ASD are associated with more severe deficits in controlling variability during precision visuomotor behavior. Differences between individuals with ASD and TD controls in the topography of networks showing relationships to visuomotor behavior suggest atypical patterns of cerebellar–cortical specialization and connectivity in ASD that underlies previously documented visuomotor deficits.
dc.description.sponsorshipNIMH K23 (MH092696)en_US
dc.description.sponsorshipNIMH R01 (MH112734)en_US
dc.description.sponsorshipKansas Center for Autism Research and Training (K-CART) Research Investment Council Strategic Initiative Granten_US
dc.description.sponsorshipNICHD U54 Kansas Intellectual and Developmental Disabilities Research Center Award (U54HD090216)en_US
dc.description.sponsorshipNational Natural Science Foundation of China Award (grant no. 81371527)en_US
dc.publisherFrontiers Mediaen_US
dc.rights© 2019 Wang, Wang, Sweeney, Gong, Lui and Mosconi.en_US
dc.subjectAutism spectrum disorderen_US
dc.subjectResting-state functional MRIen_US
dc.subjectVisuomotor controlen_US
dc.subjectPrecision gripen_US
dc.subjectCortical–cerebellar connectivityen_US
dc.subjectAmplitude of low-frequency fluctuationsen_US
dc.subjectFunctional connectivityen_US
dc.titleResting-State Brain Network Dysfunctions Associated With Visuomotor Impairments in Autism Spectrum Disorderen_US
kusw.kuauthorMosconi, Matthew W.
kusw.kudepartmentSchiefelbusch Institute for Life Span Studiesen_US
kusw.kudepartmentClinical Child Psychology Programen_US
kusw.oanotesPer Sherpa Romeo 11/19/2020:

Frontiers in Integrative Neuroscience [Open panel below]Publication Information TitleFrontiers in Integrative Neuroscience [English] ISSNsElectronic: 1662-5145 URL PublishersFrontiers Media [Commercial Publisher] DOAJ Listing Requires APCYes [Data provided by DOAJ] [Open panel below]Publisher Policy Open Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view.

Published Version NoneCC BYPMC Any Repository, Journal Website, +1 OA PublishingThis pathway includes Open Access publishing EmbargoNo Embargo LicenceCC BY 4.0 Copyright OwnerAuthors Publisher DepositPubMed Central Location Any Repository Named Repository (PubMed Central) Journal Website Conditions Published source must be acknowledged with citation Copyright must be acknowledged First publication by Frontiers Media must be acknowledged Must link to published article
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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© 2019 Wang, Wang, Sweeney, Gong, Lui and Mosconi.
Except where otherwise noted, this item's license is described as: © 2019 Wang, Wang, Sweeney, Gong, Lui and Mosconi.