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dc.contributor.authorDe Stefano, Lisa A.
dc.contributor.authorSchmitt, Lauren M.
dc.contributor.authorWhite, Stormi P.
dc.contributor.authorMosconi, Matthew W.
dc.contributor.authorSweeney, John A.
dc.contributor.authorEthridge, Lauren E.
dc.date.accessioned2020-11-17T22:05:39Z
dc.date.available2020-11-17T22:05:39Z
dc.date.issued2019-07-25
dc.identifier.citationDe Stefano, L. A., Schmitt, L. M., White, S. P., Mosconi, M. W., Sweeney, J. A., & Ethridge, L. E. (2019). Developmental Effects on Auditory Neural Oscillatory Synchronization Abnormalities in Autism Spectrum Disorder. Frontiers in integrative neuroscience, 13, 34. https://doi.org/10.3389/fnint.2019.00034en_US
dc.identifier.urihttp://hdl.handle.net/1808/30867
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractPrevious studies have found alterations in 40 Hz oscillatory activity in response to auditory stimuli in adults with Autism Spectrum Disorder (ASD). The current study sought to examine the specificity and developmental trajectory of these findings by driving the cortex to oscillate at a range of frequencies in both children and adults with and without ASD. Fifteen participants with ASD (3 female, aged 6–23 years) and 15 age-matched controls (4 female, aged 6–25 years) underwent dense-array EEG as they listened to a carrier tone amplitude-modulated by a sinusoid linearly increasing in frequency from 0–100 Hz over 2 s. EEG data were analyzed for inter-trial phase coherence (ITPC) and single-trial power (STP). Older participants with ASD displayed significantly decreased ability to phase-lock to the stimulus in the low gamma frequency range relative to their typically developing (TD) counterparts, while younger ASD and TD did not significantly differ from each other. An interaction between age and diagnosis suggested that TD and ASD also show different developmental trajectories for low gamma power; TD showed a significant decrease in low gamma power with age, while ASD did not. Regardless of age, increased low gamma STP was significantly correlated with increased clinical scores for repetitive behaviors in the ASD group, particularly insistence on sameness. This study contributes to a growing body of evidence supporting alterations in auditory processing in ASD. Older ASD participants showed more pronounced low gamma deficits than younger participants, suggesting an altered developmental trajectory for neural activity contributing to auditory processing deficits that may also be more broadly clinically relevant. Future studies are needed employing a longitudinal approach to confirm findings of this cross-sectional study.en_US
dc.description.sponsorshipNIMH Autism Center of Excellence 1P50HD055751-01en_US
dc.description.sponsorshipNIMH Autism Center of Excellence K23MH092696en_US
dc.description.sponsorshipNIMH Autism Center of Excellence K01MH087720en_US
dc.description.sponsorshipDepartment of the Army award AR100276en_US
dc.description.sponsorshipAutism Speaksen_US
dc.publisherFrontiers Mediaen_US
dc.rights© 2019 De Stefano, Schmitt, White, Mosconi, Sweeney and Ethridge.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAutism spectrum disorderen_US
dc.subjectEEGen_US
dc.subjectChirpen_US
dc.subjectSensoryen_US
dc.subjectDevelopmenten_US
dc.titleDevelopmental Effects on Auditory Neural Oscillatory Synchronization Abnormalities in Autism Spectrum Disorderen_US
dc.typeArticleen_US
kusw.kuauthorMosconi, Matthew W.
kusw.kudepartmentSchiefelbusch Institute for Life Span Studiesen_US
kusw.kudepartmentClinical Child Psychology Programen_US
dc.identifier.doi10.3389/fnint.2019.00034en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6670023en_US
dc.rights.accessrightsopenAccessen_US


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© 2019 De Stefano, Schmitt, White, Mosconi, Sweeney and Ethridge.
Except where otherwise noted, this item's license is described as: © 2019 De Stefano, Schmitt, White, Mosconi, Sweeney and Ethridge.