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dc.contributor.authorAkos, Zsuzsa
dc.contributor.authorIsai, Dona Greta
dc.contributor.authorRajasingh, Sheeja
dc.contributor.authorKosa, Edina
dc.contributor.authorGhazvini, Saba
dc.contributor.authorDhar, Prajnaparamita
dc.contributor.authorCzirok, Andras
dc.date.accessioned2020-11-10T15:16:09Z
dc.date.available2020-11-10T15:16:09Z
dc.date.issued2020-08-31
dc.identifier.citationAkos, Z., Isai, D. G., Rajasingh, S., Kosa, E., Ghazvini, S., Dhar, P., & Czirok, A. (2020). Viscoelastic Properties of ECM-Rich Embryonic Microenvironments. Frontiers in cell and developmental biology, 8, 674. https://doi.org/10.3389/fcell.2020.00674en_US
dc.identifier.urihttp://hdl.handle.net/1808/30814
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractThe material properties of tissues and their mechanical state is an important factor in development, disease, regenerative medicine and tissue engineering. Here we describe a microrheological measurement technique utilizing aggregates of microinjected ferromagnetic nickel particles to probe the viscoelastic properties of embryonic tissues. Quail embryos were cultured in a plastic incubator chamber located at the center of two pairs of crossed electromagnets. We found a pronounced viscoelastic behavior within the ECM-rich region separating the mesoderm and endoderm in Hamburger Hamilton stage 10 quail embryos, consistent with a Zener (standard generalized solid) model. The viscoelastic response is about 45% of the total response, with a characteristic relaxation time of 1.3 s.en_US
dc.description.sponsorshipNIH (R01GM102801)en_US
dc.description.sponsorshipAmerican Heart Association (19IPLOI34760594)en_US
dc.description.sponsorshipHungarian Scholarship Board's Eotvos Scholarshipen_US
dc.publisherFrontiers Mediaen_US
dc.rights© 2020 Akos, Isai, Rajasingh, Kosa, Ghazvini, Dhar and Czirok.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectECMen_US
dc.subjectQuail embryoen_US
dc.subjectMicrorheologyen_US
dc.subjectElasticityen_US
dc.subjectYoung’s modulusen_US
dc.subjectZener soliden_US
dc.subjectMagneticen_US
dc.subjectNanorodsen_US
dc.titleViscoelastic Properties of ECM-Rich Embryonic Microenvironmentsen_US
dc.typeArticleen_US
kusw.kuauthorDhar, Prajnaparamita
kusw.kudepartmentChemical & Petroleum Engineeringen_US
dc.identifier.doi10.3389/fcell.2020.00674en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC7487363en_US
dc.rights.accessrightsopenAccessen_US


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© 2020 Akos, Isai, Rajasingh, Kosa, Ghazvini, Dhar and Czirok.
Except where otherwise noted, this item's license is described as: © 2020 Akos, Isai, Rajasingh, Kosa, Ghazvini, Dhar and Czirok.