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Viscoelastic Properties of ECM-Rich Embryonic Microenvironments
dc.contributor.author | Akos, Zsuzsa | |
dc.contributor.author | Isai, Dona Greta | |
dc.contributor.author | Rajasingh, Sheeja | |
dc.contributor.author | Kosa, Edina | |
dc.contributor.author | Ghazvini, Saba | |
dc.contributor.author | Dhar, Prajnaparamita | |
dc.contributor.author | Czirok, Andras | |
dc.date.accessioned | 2020-11-10T15:16:09Z | |
dc.date.available | 2020-11-10T15:16:09Z | |
dc.date.issued | 2020-08-31 | |
dc.identifier.citation | Akos, Z., Isai, D. G., Rajasingh, S., Kosa, E., Ghazvini, S., Dhar, P., & Czirok, A. (2020). Viscoelastic Properties of ECM-Rich Embryonic Microenvironments. Frontiers in cell and developmental biology, 8, 674. https://doi.org/10.3389/fcell.2020.00674 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/30814 | |
dc.description | This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.description.abstract | The material properties of tissues and their mechanical state is an important factor in development, disease, regenerative medicine and tissue engineering. Here we describe a microrheological measurement technique utilizing aggregates of microinjected ferromagnetic nickel particles to probe the viscoelastic properties of embryonic tissues. Quail embryos were cultured in a plastic incubator chamber located at the center of two pairs of crossed electromagnets. We found a pronounced viscoelastic behavior within the ECM-rich region separating the mesoderm and endoderm in Hamburger Hamilton stage 10 quail embryos, consistent with a Zener (standard generalized solid) model. The viscoelastic response is about 45% of the total response, with a characteristic relaxation time of 1.3 s. | en_US |
dc.description.sponsorship | NIH (R01GM102801) | en_US |
dc.description.sponsorship | American Heart Association (19IPLOI34760594) | en_US |
dc.description.sponsorship | Hungarian Scholarship Board's Eotvos Scholarship | en_US |
dc.publisher | Frontiers Media | en_US |
dc.rights | © 2020 Akos, Isai, Rajasingh, Kosa, Ghazvini, Dhar and Czirok. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | ECM | en_US |
dc.subject | Quail embryo | en_US |
dc.subject | Microrheology | en_US |
dc.subject | Elasticity | en_US |
dc.subject | Young’s modulus | en_US |
dc.subject | Zener solid | en_US |
dc.subject | Magnetic | en_US |
dc.subject | Nanorods | en_US |
dc.title | Viscoelastic Properties of ECM-Rich Embryonic Microenvironments | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Dhar, Prajnaparamita | |
kusw.kudepartment | Chemical & Petroleum Engineering | en_US |
dc.identifier.doi | 10.3389/fcell.2020.00674 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC7487363 | en_US |
dc.rights.accessrights | openAccess | en_US |