dc.contributor.author | Robinson, Jennifer L. | |
dc.contributor.author | Soria, Paola | |
dc.contributor.author | Lu, Helen H. | |
dc.contributor.author | Chen, Jing | |
dc.contributor.author | Wadhwa, Sunil | |
dc.date.accessioned | 2020-10-20T15:03:17Z | |
dc.date.available | 2020-10-20T15:03:17Z | |
dc.date.issued | 2019-07-24 | |
dc.identifier.citation | Robinson, J. L., Soria, P., Lu, H. H., Chen, J., & Wadhwa, S. (2019). Structure-Function Relationships of the Temporomandibular Joint in Response to Altered Loading. Journal of oral & facial pain and headache, 33(4), 451–458. https://doi.org/10.11607/ofph.2094 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/30782 | |
dc.description.abstract | Aims:
To elucidate the effects of decreased occlusal loading (DOL), with or without reloading (RL), on the structure and bite force function of the mandibular condylar fibrocartilage in skeletally mature male mice.Methods:
At 13 weeks old, 30 wild type (WT) male mice were subjected to: (1) 6 weeks normal loading (NL); (2) 6 weeks DOL; or (3) 4 weeks DOL + 2 weeks RL. Histomorphometry, cell metabolic activity, gene expression of chondrogenic markers, and bite force tests were performed.Results:
DOL resulted in a significant increase in apoptosis (P < .0001) and significant decreases in fibrocartilage thickness (P < .05) and hypertrophic chondrocyte markers indian hedgehog and collagen type X (P < .05). A corresponding decrease in bite force was also observed (P < .05). RL treatment resulted in a return to values comparable to NL of chondrogenic maturation markers (P > .10), apoptosis (P > .999), and bite force (P > .90), but not in mandibular condylar fibrocartilage thickness (P > .05).Conclusions:
DOL in skeletally mature mice induces mandibular condylar fibrocartilage atrophy at the hypertrophic cell layer with a corresponding decrease in bite force. | en_US |
dc.description.sponsorship | R56 DE020097 | en_US |
dc.description.sponsorship | F32 DE026366 | en_US |
dc.description.sponsorship | French Federation of Orthodontics | en_US |
dc.publisher | Quintessence Publishing | en_US |
dc.rights | © 2019 Quintessence Publishing Co, Inc | en_US |
dc.subject | Bite force | en_US |
dc.subject | Chondrogenesis | en_US |
dc.subject | Decreased occlusal loading | en_US |
dc.subject | Mandibular condylar fibrocartilage | en_US |
dc.subject | Masticatory function | en_US |
dc.title | Structure-Function Relationships of the Temporomandibular Joint in Response to Altered Loading | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Robinson, Jennifer L. | |
kusw.kudepartment | Chemical and Petroleum Engineering | en_US |
dc.identifier.doi | 10.11607/ofph.2094 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC7204988 | en_US |
dc.rights.accessrights | openAccess | en_US |