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dc.contributor.authorRobinson, Jennifer L.
dc.contributor.authorSoria, Paola
dc.contributor.authorLu, Helen H.
dc.contributor.authorChen, Jing
dc.contributor.authorWadhwa, Sunil
dc.date.accessioned2020-10-20T15:03:17Z
dc.date.available2020-10-20T15:03:17Z
dc.date.issued2019-07-24
dc.identifier.citationRobinson, J. L., Soria, P., Lu, H. H., Chen, J., & Wadhwa, S. (2019). Structure-Function Relationships of the Temporomandibular Joint in Response to Altered Loading. Journal of oral & facial pain and headache, 33(4), 451–458. https://doi.org/10.11607/ofph.2094en_US
dc.identifier.urihttp://hdl.handle.net/1808/30782
dc.description.abstractAims: To elucidate the effects of decreased occlusal loading (DOL), with or without reloading (RL), on the structure and bite force function of the mandibular condylar fibrocartilage in skeletally mature male mice.

Methods: At 13 weeks old, 30 wild type (WT) male mice were subjected to: (1) 6 weeks normal loading (NL); (2) 6 weeks DOL; or (3) 4 weeks DOL + 2 weeks RL. Histomorphometry, cell metabolic activity, gene expression of chondrogenic markers, and bite force tests were performed.

Results: DOL resulted in a significant increase in apoptosis (P < .0001) and significant decreases in fibrocartilage thickness (P < .05) and hypertrophic chondrocyte markers indian hedgehog and collagen type X (P < .05). A corresponding decrease in bite force was also observed (P < .05). RL treatment resulted in a return to values comparable to NL of chondrogenic maturation markers (P > .10), apoptosis (P > .999), and bite force (P > .90), but not in mandibular condylar fibrocartilage thickness (P > .05).

Conclusions: DOL in skeletally mature mice induces mandibular condylar fibrocartilage atrophy at the hypertrophic cell layer with a corresponding decrease in bite force.
en_US
dc.description.sponsorshipR56 DE020097en_US
dc.description.sponsorshipF32 DE026366en_US
dc.description.sponsorshipFrench Federation of Orthodonticsen_US
dc.publisherQuintessence Publishingen_US
dc.rights© 2019 Quintessence Publishing Co, Incen_US
dc.subjectBite forceen_US
dc.subjectChondrogenesisen_US
dc.subjectDecreased occlusal loadingen_US
dc.subjectMandibular condylar fibrocartilageen_US
dc.subjectMasticatory functionen_US
dc.titleStructure-Function Relationships of the Temporomandibular Joint in Response to Altered Loadingen_US
dc.typeArticleen_US
kusw.kuauthorRobinson, Jennifer L.
kusw.kudepartmentChemical and Petroleum Engineeringen_US
dc.identifier.doi10.11607/ofph.2094en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC7204988en_US
dc.rights.accessrightsopenAccessen_US


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