Show simple item record

dc.contributor.authorEscobar, Luis E.
dc.contributor.authorPritzkow, Sandra
dc.contributor.authorWinter, Steven N.
dc.contributor.authorGrear, Daniel A.
dc.contributor.authorKirchgessner, Megan S.
dc.contributor.authorDominguez-Villegas, Ernesto
dc.contributor.authorMachado, Gustavo
dc.contributor.authorPeterson, A. Townsend
dc.contributor.authorSoto, Claudio
dc.date.accessioned2020-06-18T20:50:51Z
dc.date.available2020-06-18T20:50:51Z
dc.date.issued2020-04-01
dc.identifier.citationEscobar, L. E., Pritzkow, S., Winter, S. N., Grear, D. A., Kirchgessner, M. S., Dominguez-Villegas, E., Machado, G., Townsend Peterson, A., & Soto, C. (2020). The ecology of chronic wasting disease in wildlife. Biological reviews of the Cambridge Philosophical Society, 95(2), 393–408. https://doi.org/10.1111/brv.12568en_US
dc.identifier.urihttp://hdl.handle.net/1808/30555
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractPrions are misfolded infectious proteins responsible for a group of fatal neurodegenerative diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic Wasting Disease (CWD) is the prion disease with the highest spillover potential, affecting at least seven Cervidae (deer) species. The zoonotic potential of CWD is inconclusive and cannot be ruled out. A risk of infection for other domestic and wildlife species is also plausible. Here, we review the current status of the knowledge with respect to CWD ecology in wildlife. Our current understanding of the geographic distribution of CWD lacks spatial and temporal detail, does not consider the biogeography of infectious diseases, and is largely biased by sampling based on hunters’ cooperation and funding available for each region. Limitations of the methods used for data collection suggest that the extent and prevalence of CWD in wildlife is underestimated. If the zoonotic potential of CWD is confirmed in the short term, as suggested by recent results obtained in experimental animal models, there will be limited accurate epidemiological data to inform public health. Research gaps in CWD prion ecology include the need to identify specific biological characteristics of potential CWD reservoir species that better explain susceptibility to spillover, landscape and climate configurations that are suitable for CWD transmission, and the magnitude of sampling bias in our current understanding of CWD distribution and risk. Addressing these research gaps will help anticipate novel areas and species where CWD spillover is expected, which will inform control strategies. From an ecological perspective, control strategies could include assessing restoration of natural predators of CWD reservoirs, ultrasensitive CWD detection in biotic and abiotic reservoirs, and deer density and landscape modification to reduce CWD spread and prevalence.en_US
dc.publisherWileyen_US
dc.rights© 2019 Cambridge Philosophical Societyen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCervidaeen_US
dc.subjectChronic Wasting Diseaseen_US
dc.subjectCWDen_US
dc.subjectPrionsen_US
dc.subjectReservoirsen_US
dc.subjectSpreaden_US
dc.subjectWildlifeen_US
dc.subjectZoonoticen_US
dc.titleThe ecology of chronic wasting disease in wildlifeen_US
dc.typeArticleen_US
kusw.kuauthorPeterson, A. Townsend
kusw.kudepartmentEcology and Evolutionary Biologyen_US
kusw.kudepartmentBiodiversity Instituteen_US
dc.identifier.doi10.1111/brv.12568en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC7085120en_US
dc.rights.accessrightsopenAccessen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

© 2019 Cambridge Philosophical Society
Except where otherwise noted, this item's license is described as: © 2019 Cambridge Philosophical Society