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Conformational Stability Effect of Polymeric Iron Chelators
dc.contributor.author | Qian, Jian | |
dc.contributor.author | Berkland, Cory | |
dc.date.accessioned | 2020-06-12T19:05:14Z | |
dc.date.available | 2020-06-12T19:05:14Z | |
dc.date.issued | 2019-10-14 | |
dc.identifier.citation | Qian, J., & Berkland, C. (2019). Conformational Stability Effect of Polymeric Iron Chelators. iScience, 21, 124–134. https://doi.org/10.1016/j.isci.2019.10.022 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/30460 | |
dc.description | This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.description.abstract | The design and synthesis of metal chelators with extraordinary metal affinities is a basic and challenging scientific problem of both fundamental and practical importance. Here, we demonstrate a “conformational stability effect” that can significantly enhance the metal affinity of ligands after conjugation to polymer chains with the ability to spontaneously adopt a specific conformation as an optimal “soft” scaffold to ensure maximum thermodynamic stability of the metal complexes. Using iron chelators as models, we show that simple conjugation of small molecule catechol ligands to a polyallylamine chain resulted in more than 8–9 orders of magnitude enhancement of the iron-binding affinity, which is comparable to that of enterobactin, the strongest iron chelator ever known. This study demonstrates that flexible polymer chelators may realize the highest possible metal affinities of the conjugated ligands owing to their ability to achieve an optimal conformation, which could advance the identification of strong metal chelators. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2019 The Author(s). | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Polymer Chemistry | en_US |
dc.subject | Chemical Synthesis | en_US |
dc.subject | Polymers | en_US |
dc.title | Conformational Stability Effect of Polymeric Iron Chelators | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Qian, Jian | |
kusw.kuauthor | Berkland, Cory | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
kusw.kudepartment | Chemical and Petroleum Engineering | en_US |
dc.identifier.doi | 10.1016/j.isci.2019.10.022 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC6820273 | en_US |
dc.rights.accessrights | openAccess | en_US |