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dc.contributor.authorRoy, Anuradha
dc.contributor.authorMcDonald, Peter
dc.contributor.authorTimmermann, Barbara N.
dc.contributor.authorGupta, Mahabir
dc.contributor.authorChaguturu, Rathnam
dc.date.accessioned2020-03-26T21:09:44Z
dc.date.available2020-03-26T21:09:44Z
dc.date.issued2019-01-01
dc.identifier.citationRoy, A., McDonald, P., Timmermann, B. N., Gupta, M., & Chaguturu, R. (2019). Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening. Natural product communications, 14(1), 71–74. https://doi.org/10.1177/1934578X1901400119en_US
dc.identifier.urihttp://hdl.handle.net/1808/30194
dc.descriptionThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.en_US
dc.description.abstractWe report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected, taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were used for profiling selected bioactivities. Assays were performed to evaluate the antioxidant activity of the extracts for Antioxidant Response Element (ARE) induction, total non-enzymatic antioxidant potential, anti-inflammatory and anticancer properties. The high throughput analysis of 280 extracts resulted in identification of 57.5% of the extracts that could induce ARE at one or more concentrations tested, 93.5% that harbored total antioxidant capacity, and 2.1% of the extracts that showed lung cancer cell line-specific cytotoxicity. Data from our profiling experiments indicate that a large number of extracts could be a source for further isolation and chemical identification of compounds that could serve as leads for discovery of antioxidant, anticancer and anti-inflammatory agents to prevent or treat complex diseases like cancer and neurodegenerative disorders.en_US
dc.publisherSAGE Publicationsen_US
dc.rightsCopyright © 2019 SAGE Publications. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en_US
dc.subjectBioprospectionen_US
dc.subjectPlantsen_US
dc.subjectPanamaen_US
dc.subjectBiomedicineen_US
dc.subjectScreeningen_US
dc.subjectCanceren_US
dc.subjectAlzheimeren_US
dc.subjectAnti-inflammationen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectAntioxidant Response Elementen_US
dc.subjectCytotoxicityen_US
dc.subjectIL-2en_US
dc.titleBioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screeningen_US
dc.typeArticleen_US
kusw.kuauthorRoy, Anuradha
kusw.kuauthorMcDonald, Peter
kusw.kuauthorTimmermann, Barbara N.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1177/1934578X1901400119en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6959481en_US
dc.rights.accessrightsopenAccessen_US


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Copyright © 2019 SAGE Publications.  This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Except where otherwise noted, this item's license is described as: Copyright © 2019 SAGE Publications. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.