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Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening
dc.contributor.author | Roy, Anuradha | |
dc.contributor.author | McDonald, Peter | |
dc.contributor.author | Timmermann, Barbara N. | |
dc.contributor.author | Gupta, Mahabir | |
dc.contributor.author | Chaguturu, Rathnam | |
dc.date.accessioned | 2020-03-26T21:09:44Z | |
dc.date.available | 2020-03-26T21:09:44Z | |
dc.date.issued | 2019-01-01 | |
dc.identifier.citation | Roy, A., McDonald, P., Timmermann, B. N., Gupta, M., & Chaguturu, R. (2019). Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening. Natural product communications, 14(1), 71–74. https://doi.org/10.1177/1934578X1901400119 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/30194 | |
dc.description | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. | en_US |
dc.description.abstract | We report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected, taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were used for profiling selected bioactivities. Assays were performed to evaluate the antioxidant activity of the extracts for Antioxidant Response Element (ARE) induction, total non-enzymatic antioxidant potential, anti-inflammatory and anticancer properties. The high throughput analysis of 280 extracts resulted in identification of 57.5% of the extracts that could induce ARE at one or more concentrations tested, 93.5% that harbored total antioxidant capacity, and 2.1% of the extracts that showed lung cancer cell line-specific cytotoxicity. Data from our profiling experiments indicate that a large number of extracts could be a source for further isolation and chemical identification of compounds that could serve as leads for discovery of antioxidant, anticancer and anti-inflammatory agents to prevent or treat complex diseases like cancer and neurodegenerative disorders. | en_US |
dc.publisher | SAGE Publications | en_US |
dc.rights | Copyright © 2019 SAGE Publications. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en_US |
dc.subject | Bioprospection | en_US |
dc.subject | Plants | en_US |
dc.subject | Panama | en_US |
dc.subject | Biomedicine | en_US |
dc.subject | Screening | en_US |
dc.subject | Cancer | en_US |
dc.subject | Alzheimer | en_US |
dc.subject | Anti-inflammation | en_US |
dc.subject | Total Antioxidant Capacity | en_US |
dc.subject | Antioxidant Response Element | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | IL-2 | en_US |
dc.title | Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Roy, Anuradha | |
kusw.kuauthor | McDonald, Peter | |
kusw.kuauthor | Timmermann, Barbara N. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1177/1934578X1901400119 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC6959481 | en_US |
dc.rights.accessrights | openAccess | en_US |