Abstract
We report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected, taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were used for profiling selected bioactivities. Assays were performed to evaluate the antioxidant activity of the extracts for Antioxidant Response Element (ARE) induction, total non-enzymatic antioxidant potential, anti-inflammatory and anticancer properties. The high throughput analysis of 280 extracts resulted in identification of 57.5% of the extracts that could induce ARE at one or more concentrations tested, 93.5% that harbored total antioxidant capacity, and 2.1% of the extracts that showed lung cancer cell line-specific cytotoxicity. Data from our profiling experiments indicate that a large number of extracts could be a source for further isolation and chemical identification of compounds that could serve as leads for discovery of antioxidant, anticancer and anti-inflammatory agents to prevent or treat complex diseases like cancer and neurodegenerative disorders.
Description
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Citation
Roy, A., McDonald, P., Timmermann, B. N., Gupta, M., & Chaguturu, R. (2019). Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening. Natural product communications, 14(1), 71–74. https://doi.org/10.1177/1934578X1901400119