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Maternal Vitamin D Status and Infant Infection
dc.contributor.author | Moukarzel, Sara | |
dc.contributor.author | Ozias, Marlies | |
dc.contributor.author | Kerling, Elizabeth | |
dc.contributor.author | Christifano, Danielle | |
dc.contributor.author | Wick, Jo | |
dc.contributor.author | Colombo, John | |
dc.contributor.author | Carlson, Susan | |
dc.date.accessioned | 2019-11-08T17:44:18Z | |
dc.date.available | 2019-11-08T17:44:18Z | |
dc.date.issued | 2018-01-23 | |
dc.identifier.citation | Moukarzel, S.; Ozias, M.; Kerling, E.; Christifano, D.; Wick, J.; Colombo, J.; Carlson, S. Maternal Vitamin D Status and Infant Infection. Nutrients 2018, 10, 111. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/29745 | |
dc.description.abstract | Maternal vitamin D status during pregnancy may modulate fetal immune system development and infant susceptibility to infections. Vitamin D deficiency is common during pregnancy, particularly among African American (AA) women. Our objective was to compare maternal vitamin D status (plasma 25(OH)D concentration) during pregnancy and first-year infections in the offspring of African American (AA) and non-AA women. We used medical records to record frequency and type of infections during the first year of life of 220 term infants (69 AA, 151 non-AA) whose mothers participated in the Kansas University DHA Outcomes Study. AA and non-AA groups were compared for maternal 25(OH)D by Mann–Whitney U-test. Compared to non-AA women, AA women were more likely to be vitamin D deficient (<50 nmol/L; 84 vs. 37%, p < 0.001), and more of their infants had at least one infection in the first 6 months (78.3% and 59.6% of infants, respectively, p = 0.022). We next explored the relationship between maternal plasma 25(OH)D concentration and infant infections using Spearman correlations. Maternal 25(OH)D concentration was inversely correlated with the number of all infections (p = 0.033), eye, ear, nose, and throat (EENT) infections (p = 0.043), and skin infection (p = 0.021) in the first 6 months. A model that included maternal education, income, and 25(OH)D identified maternal education as the only significant predictor of infection risk in the first 6 months (p = 0.045); however, maternal education, income, and 25(OH)D were all significantly lower in AA women compared to non-AA women . The high degree of correlation between these variables does not allow determination of which factor is driving the risk of infection; however, the one that is most easily remediated is vitamin D status. It would be of value to learn if vitamin D supplementation in this at-risk group could ameliorate at least part of the increased infection risk | en_US |
dc.description.sponsorship | This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Development (R01 HD047315 [to SC]) | en_US |
dc.description.sponsorship | the Kansas Intellectual and Developmental Disabilities Research Center (P30 HD002528 [to SC and JC]) | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | infection | en_US |
dc.subject | 25-hydroxycholecalciferol | en_US |
dc.subject | vitamin D | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | infancy | en_US |
dc.subject | maternal nutrition | en_US |
dc.subject | African Americans | en_US |
dc.title | Maternal Vitamin D Status and Infant Infection | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Kerling, Elizabeth | |
kusw.kuauthor | Christifano, Danielle | |
kusw.kuauthor | Wick, Jo | |
kusw.kuauthor | Colombo, John | |
kusw.kuauthor | Carlson, Susan | |
kusw.kudepartment | Dietetics | en_US |
kusw.kudepartment | Psychology | en_US |
kusw.kudepartment | biostatistics | en_US |
dc.identifier.doi | 10.3390/nu10020111 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
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