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Metal-Templated Assembly of Cyclopropane-Fused Diazepanones and Diazecanones via exo-trig Nucleophilic Cyclization of Cyclopropenes with Tethered Carbamates

dc.contributor.authorMaslivetc, Vladimir A.
dc.contributor.authorFrolova, Liliya V.
dc.contributor.authorRogelj, Snezna
dc.contributor.authorMaslivetc, Anna A.
dc.contributor.authorRubina, Marina
dc.contributor.authorRubin, Michael
dc.date.accessioned2019-11-07T22:08:53Z
dc.date.available2019-11-07T22:08:53Z
dc.date.issued2018-10-24
dc.identifier.citationMaslivetc, V. A., Frolova, L. V., Rogelj, S., Maslivetc, A. A., Rubina, M., & Rubin, M. (2018). Metal-Templated Assembly of Cyclopropane-Fused Diazepanones and Diazecanones via exo- trig Nucleophilic Cyclization of Cyclopropenes with Tethered Carbamates. The Journal of organic chemistry, 83(22), 13743–13753. doi:10.1021/acs.joc.8b02062en_US
dc.identifier.urihttp://hdl.handle.net/1808/29735
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/acs.joc.8b02062.en_US
dc.description.abstractA strain-release-driven, cation-templated nucleophilic 7- and 8-exo-trig-cyclization of tethered Boc-protected amines to cyclopropenes is described. The featured reaction proceeds in diastereo- and regioselective fashion and allows for preparation of the corresponding 2,5-diazabicyclo[5.1.0]octan-6-ones and 2,6-diazabicyclo[6.1.0]nonan-7-ones as sole products in high yields. Preliminary studies on anticancer activities of these novel cyclopropane-fused medium heterocycles were performed.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsCopyright © 2018 American Chemical Societyen_US
dc.titleMetal-Templated Assembly of Cyclopropane-Fused Diazepanones and Diazecanones via exo-trig Nucleophilic Cyclization of Cyclopropenes with Tethered Carbamatesen_US
dc.typeArticleen_US
kusw.kuauthorMaslivetc, Vladimir A.
kusw.kuauthorMaslivetc, Anna A.
kusw.kuauthorRubina, Rubina
kusw.kuauthorRubin, Michael
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1021/acs.joc.8b02062en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1673-6365en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1668-9311en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6667834en_US
dc.rights.accessrightsopenAccessen_US


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