Metal-Templated Assembly of Cyclopropane-Fused Diazepanones and Diazecanones via exo-trig Nucleophilic Cyclization of Cyclopropenes with Tethered Carbamates

Maslivetc, Vladimir A.; Frolova, Liliya V.; Rogelj, Snezna; Maslivetc, Anna A.; Rubina, Marina; Rubin, Michael

dc.contributor.author	Maslivetc, Vladimir A.
dc.contributor.author	Frolova, Liliya V.
dc.contributor.author	Rogelj, Snezna
dc.contributor.author	Maslivetc, Anna A.
dc.contributor.author	Rubina, Marina
dc.contributor.author	Rubin, Michael
dc.date.accessioned	2019-11-07T22:08:53Z
dc.date.available	2019-11-07T22:08:53Z
dc.date.issued	2018-10-24
dc.identifier.citation	Maslivetc, V. A., Frolova, L. V., Rogelj, S., Maslivetc, A. A., Rubina, M., & Rubin, M. (2018). Metal-Templated Assembly of Cyclopropane-Fused Diazepanones and Diazecanones via exo- trig Nucleophilic Cyclization of Cyclopropenes with Tethered Carbamates. The Journal of organic chemistry, 83(22), 13743–13753. doi:10.1021/acs.joc.8b02062	en_US
dc.identifier.uri	http://hdl.handle.net/1808/29735
dc.description	This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/acs.joc.8b02062.	en_US
dc.description.abstract	A strain-release-driven, cation-templated nucleophilic 7- and 8-exo-trig-cyclization of tethered Boc-protected amines to cyclopropenes is described. The featured reaction proceeds in diastereo- and regioselective fashion and allows for preparation of the corresponding 2,5-diazabicyclo[5.1.0]octan-6-ones and 2,6-diazabicyclo[6.1.0]nonan-7-ones as sole products in high yields. Preliminary studies on anticancer activities of these novel cyclopropane-fused medium heterocycles were performed.	en_US
dc.publisher	American Chemical Society	en_US
dc.rights	Copyright © 2018 American Chemical Society	en_US
dc.title	Metal-Templated Assembly of Cyclopropane-Fused Diazepanones and Diazecanones via exo-trig Nucleophilic Cyclization of Cyclopropenes with Tethered Carbamates	en_US
dc.type	Article	en_US
kusw.kuauthor	Maslivetc, Vladimir A.
kusw.kuauthor	Maslivetc, Anna A.
kusw.kuauthor	Rubina, Rubina
kusw.kuauthor	Rubin, Michael
kusw.kudepartment	Chemistry	en_US
dc.identifier.doi	10.1021/acs.joc.8b02062	en_US
dc.identifier.orcid	https://orcid.org/0000-0003-1673-6365	en_US
dc.identifier.orcid	https://orcid.org/0000-0002-1668-9311	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC6667834	en_US
dc.rights.accessrights	openAccess	en_US

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