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dc.contributor.advisorFry, Andrew C
dc.contributor.authorNicoll, Justin
dc.date.accessioned2019-01-01T19:32:27Z
dc.date.available2019-01-01T19:32:27Z
dc.date.issued2018-05-31
dc.date.submitted2018
dc.identifier.otherhttp://dissertations.umi.com/ku:15950
dc.identifier.urihttp://hdl.handle.net/1808/27562
dc.description.abstractMitogen-activated protein kinases (MAPK) ERK, JNK, and p38 are a family of signal transduction proteins that respond to diverse forms of physiological stress including exercise. MAPK appear to mediate several adaptations to exercise skeletal muscle however most of their data are limited to cell culture, animal or endurance training study designs. Increasing evidence suggests they mediate translational efficiency and capacity. Further, recent data indicates they can regulate the steroid androgen (AR) and glucocorticoid (GR) receptors via phosphorylation. However, there are no data investigating AR and GR phosphorylation in humans or their response to resistance exercise (RE). Thus, understanding how MAPK, AR, and GR phosphorylation respond during resistance exercise will give us better insight to their specific roles in muscle adaptation. This dissertation investigated the activation of MAPK and epinephrine receptor signaling to a caffeine containing pre-workout supplement during resistance exercise. Further, we also described MAPK expression and phosphorylated AR and GR in resting skeletal muscle between males and females. Finally, we conducted a training study to determine differences in MAPK, AR, and GR phosphorylation following a period of stressful resistance training. The results of this dissertation indicates 1) pre-workout supplementation improves performance but does not enhance MAPK or epinephrine receptor signaling early after RE, 2) males and females express different expression of phosphorylated AR, GR, and p38 at rest, 3) MAPK and phosphorylated AR and GR are activated after acute RE and are differentially regulated following a period of short-term stressful training.
dc.format.extent258 pages
dc.language.isoen
dc.publisherUniversity of Kansas
dc.rightsCopyright held by the author.
dc.subjectKinesiology
dc.subjectcell signaling
dc.subjectovertraining
dc.subjectsex differences
dc.subjectskeletal muscle
dc.subjectsteroid receptors
dc.subjectsupplementation
dc.titleMAPK Signaling and Intracellular Hormone Receptor Phosphorylation at Rest and Following Resistance Training
dc.typeDissertation
dc.contributor.cmtememberGallagher, Philip M
dc.contributor.cmtememberHerda, Trent J
dc.contributor.cmtememberTaylor, Jordan M
dc.contributor.cmtememberAltman, Ryan A
dc.thesis.degreeDisciplineHealth, Sport and Exercise Sciences
dc.thesis.degreeLevelPh.D.
dc.identifier.orcid
dc.rights.accessrightsopenAccess


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