MAPK Signaling and Intracellular Hormone Receptor Phosphorylation at Rest and Following Resistance Training
Issue Date
2018-05-31Author
Nicoll, Justin
Publisher
University of Kansas
Format
258 pages
Type
Dissertation
Degree Level
Ph.D.
Discipline
Health, Sport and Exercise Sciences
Rights
Copyright held by the author.
Metadata
Show full item recordAbstract
Mitogen-activated protein kinases (MAPK) ERK, JNK, and p38 are a family of signal transduction proteins that respond to diverse forms of physiological stress including exercise. MAPK appear to mediate several adaptations to exercise skeletal muscle however most of their data are limited to cell culture, animal or endurance training study designs. Increasing evidence suggests they mediate translational efficiency and capacity. Further, recent data indicates they can regulate the steroid androgen (AR) and glucocorticoid (GR) receptors via phosphorylation. However, there are no data investigating AR and GR phosphorylation in humans or their response to resistance exercise (RE). Thus, understanding how MAPK, AR, and GR phosphorylation respond during resistance exercise will give us better insight to their specific roles in muscle adaptation. This dissertation investigated the activation of MAPK and epinephrine receptor signaling to a caffeine containing pre-workout supplement during resistance exercise. Further, we also described MAPK expression and phosphorylated AR and GR in resting skeletal muscle between males and females. Finally, we conducted a training study to determine differences in MAPK, AR, and GR phosphorylation following a period of stressful resistance training. The results of this dissertation indicates 1) pre-workout supplementation improves performance but does not enhance MAPK or epinephrine receptor signaling early after RE, 2) males and females express different expression of phosphorylated AR, GR, and p38 at rest, 3) MAPK and phosphorylated AR and GR are activated after acute RE and are differentially regulated following a period of short-term stressful training.
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