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Total Synthesis and Structure–Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine)
| dc.contributor.author | Pashikanti, Srinath | |
| dc.contributor.author | Ukani, Rehman | |
| dc.contributor.author | David, Sunil A. | |
| dc.contributor.author | Datta, Apurba | |
| dc.date.accessioned | 2018-11-01T18:00:49Z | |
| dc.date.available | 2018-11-01T18:00:49Z | |
| dc.date.issued | 2017 | |
| dc.identifier.citation | Pashikanti, S., Rehnman, U., David, S. A., Apurba, D., (2017), FTotal Synthesis and Structure–Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine), Synthesis, https://doi.org/10.1055/s-0036-1588118 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/27129 | |
| dc.description.abstract | By utilizing an l-serine-derived bicyclic lactone as an advanced chiral building block, a short synthetic route to the cytotoxic marine natural product jaspine B has been developed. Targeting structure–activity relationship investigations, the synthetic route has also been utilized for the synthesis and cytotoxicity evaluation of strategically modified jaspine B analogues. In addition, a previously reported synthesis of the title natural product from our research has been reinvestigated to clarify the sterochemical assignment. | en_US |
| dc.publisher | Thieme Publishing | en_US |
| dc.subject | Jaspine B | en_US |
| dc.subject | Stereochemistry | en_US |
| dc.subject | Cytotoxic | en_US |
| dc.subject | Drug development | en_US |
| dc.subject | Structure | en_US |
| dc.subject | Activity relationships | en_US |
| dc.title | Total Synthesis and Structure–Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine) | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Dutta, Apurba | |
| kusw.kudepartment | Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.1055/s-0036-1588118 | en_US |
| kusw.oaversion | Scholarly/refereed, publisher version | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess | en_US |
