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    Total Synthesis and Structure–Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine)

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    Pashikanti_2017.pdf (271.9Kb)
    Issue Date
    2017
    Author
    Pashikanti, Srinath
    Ukani, Rehman
    David, Sunil A.
    Datta, Apurba
    Publisher
    Thieme Publishing
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    By utilizing an l-serine-derived bicyclic lactone as an advanced chiral building block, a short synthetic route to the cytotoxic marine natural product jaspine B has been developed. Targeting structure–activity relationship investigations, the synthetic route has also been utilized for the synthesis and cytotoxicity evaluation of strategically modified jaspine B analogues. In addition, a previously reported synthesis of the title natural product from our research has been reinvestigated to clarify the sterochemical assignment.
    URI
    http://hdl.handle.net/1808/27129
    DOI
    https://doi.org/10.1055/s-0036-1588118
    Collections
    • Medicinal Chemistry Scholarly Works [242]
    Citation
    Pashikanti, S., Rehnman, U., David, S. A., Apurba, D., (2017), FTotal Synthesis and Structure–Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine), Synthesis, https://doi.org/10.1055/s-0036-1588118

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    KU Libraries
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    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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