dc.contributor.author | Saunders, Kevin O. | |
dc.contributor.author | Nicely, Nathan | |
dc.contributor.author | Wiehe, Kevin | |
dc.contributor.author | Bonsignori, Mattia | |
dc.contributor.author | Meyerhoff, R. Ryan | |
dc.contributor.author | Parks, Robert | |
dc.contributor.author | Walkowicz, William E. | |
dc.contributor.author | Aussedat, Baptiste | |
dc.contributor.author | Wu, Nelson R. | |
dc.contributor.author | Cai, Fangping | |
dc.contributor.author | Yusuf, Vohra | |
dc.contributor.author | Park, Peter K. | |
dc.contributor.author | Eaton, Amanda | |
dc.contributor.author | Go, Eden P. | |
dc.contributor.author | Sutherland, Laura L. | |
dc.contributor.author | Scearce, Richard M. | |
dc.contributor.author | Barouch, Dan H. | |
dc.contributor.author | Zhang, Ruijun | |
dc.contributor.author | Von Holle, Tarra | |
dc.contributor.author | Overman, Glenn | |
dc.contributor.author | Anasti, Kara | |
dc.contributor.author | Sanders, Rogier W. | |
dc.contributor.author | Moody, M. Anthony | |
dc.contributor.author | Kepler, Thomas B. | |
dc.contributor.author | Korber, Bette | |
dc.contributor.author | Desaire, Heather | |
dc.contributor.author | Santra, Sampa | |
dc.contributor.author | Letvin, Norman L. | |
dc.contributor.author | Nabel, Gary J. | |
dc.contributor.author | Montefiori, David C. | |
dc.contributor.author | Tomaras, Georgia D. | |
dc.contributor.author | Liao, Hua-Xin | |
dc.contributor.author | Alam, S. Munir | |
dc.contributor.author | Danishefsky, Samuel J. | |
dc.contributor.author | Haynes, Barton F. | |
dc.date.accessioned | 2018-11-01T17:40:45Z | |
dc.date.available | 2018-11-01T17:40:45Z | |
dc.date.issued | 2017-02-28 | |
dc.identifier.citation | Saunders, K., Nicely, N. I., Wiehe, K., (2017), Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates, Cell Reports, https://doi.org/10.1073/pnas.1615660114 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/27127 | |
dc.description.abstract | Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antibodies to the V3-glycan bnAb binding site, we repetitively immunized macaques over a 4-year period with an Env expressing V3-high mannose glycans. Env immunizations elicited plasma antibodies that neutralized HIV-1 expressing only high-mannose glycans—a characteristic shared by early bnAb B cell lineage members. A rhesus recombinant monoclonal antibody from a vaccinated macaque bound to the V3-glycan site at the same amino acids as broadly neutralizing antibodies. A structure of the antibody bound to glycan revealed that the three variable heavy-chain complementarity-determining regions formed a cavity into which glycan could insert and neutralized multiple HIV-1 isolates with high-mannose glycans. Thus, HIV-1 Env vaccination induced mannose-dependent antibodies with characteristics of V3-glycan bnAb precursors. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.title | Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Desaire, Heather | |
kusw.kudepartment | Chemistry | en_US |
dc.identifier.doi | 10.1016/j.celrep.2017.02.003 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |