ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
CELLULAR PATHWAY DEREGULATION AND POTENTIAL TARGETED THERAPY FOR ADULT T-CELL LEUKEMIA
dc.contributor.advisor | Nicot, Christophe | |
dc.contributor.author | Moles, Ramona | |
dc.date.accessioned | 2018-10-25T16:14:03Z | |
dc.date.available | 2018-10-25T16:14:03Z | |
dc.date.issued | 2017-12-31 | |
dc.date.submitted | 2017 | |
dc.identifier.other | http://dissertations.umi.com/ku:15637 | |
dc.identifier.uri | http://hdl.handle.net/1808/27030 | |
dc.description.abstract | Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of Adult T-cell Leukemia (ATL), a lymphoproliferative disorder with a very poor prognosis. While approximatively 5% of individuals infected with HTLV-1 develop ATL within twenty years of first infection, the molecular mechanism that the virus uses to induce ATL is not entirely understood. microRNAs are posttranscriptional regulators involved in a wide range of biological processes. Based on biological functions, alteration of their expression can potentially contribute to tumor initiation and progression. The purpose of this thesis is to study changes in miRNA expression and their role in the deregulation of cellular pathways essential in HTLV-1-transformed and ATL cells. Moreover, the absence of an effective treatment for patients led to investigation of potential therapeutic strategies for ATL. Since previous findings show that DNA repair is impaired in HTLV-1-transformed cells, this thesis is focused on targeting DNA repair as a new therapeutic option in ATL. More specifically, the aim is the study of antiproliferative effects and cytotoxicity of PARP and helicase inhibitors in HTLV-1-transformed and ATL cells. | |
dc.format.extent | 344 pages | |
dc.language.iso | en | |
dc.publisher | University of Kansas | |
dc.rights | Copyright held by the author. | |
dc.subject | Health sciences | |
dc.title | CELLULAR PATHWAY DEREGULATION AND POTENTIAL TARGETED THERAPY FOR ADULT T-CELL LEUKEMIA | |
dc.type | Dissertation | |
dc.thesis.degreeDiscipline | Pathology & Laboratory Medicine | |
dc.thesis.degreeLevel | Ph.D. | |
dc.identifier.orcid | ||
dc.rights.accessrights | openAccess |
Files in this item
This item appears in the following Collection(s)
-
Dissertations [4889]
-
KU Med Center Dissertations and Theses [464]