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dc.contributor.authorHe, Shanshan
dc.contributor.authorJain, Prashi
dc.contributor.authorLin, Billy
dc.contributor.authorFerrer, Mark
dc.contributor.authorHu, Zongyi
dc.contributor.authorSouthall, Noel
dc.contributor.authorHu, Xin
dc.contributor.authorZheng, Wei
dc.contributor.authorNeuenswander, Benjamin
dc.contributor.authorCho, Chul-Hee
dc.contributor.authorChen, Yu
dc.contributor.authorWorlikar, Shilpa A.
dc.contributor.authorAubé, Jeffrey
dc.contributor.authorLarock, Richard C.
dc.contributor.authorSchoenen, Frank J.
dc.contributor.authorMarugan, Juan J.
dc.contributor.authorLiang, T. Jake
dc.contributor.authorFrankowski, Kevin J.
dc.date.accessioned2018-09-14T17:36:03Z
dc.date.available2018-09-14T17:36:03Z
dc.date.issued2015-09-02
dc.identifier.citationShanshan He, Prashi Jain, Billy Lin, Marc Ferrer, Zongyi Hu, Noel Southall, Xin Hu, Wei Zheng, Benjamin Neuenswander, Chul-Hee Cho, Yu Chen, Shilpa A. Worlikar, Jeffrey Aubé, Richard C. Larock, Frank J. Schoenen, Juan J. Marugan, T. Jake Liang, Kevin J. Frankowski ACS Comb Sci. 2015 Oct 12; 17(10): 641–652. Published online 2015 Sep 17. doi: 10.1021/acscombsci.5b00101en_US
dc.identifier.urihttp://hdl.handle.net/1808/26723
dc.description.abstractUsing a high-throughput, cell-based HCV luciferase reporter assay to screen a diverse small-molecule compound collection (~300 000 compounds), we identified a benzofuran compound class of HCV inhibitors. The optimization of the benzofuran scaffold led to the identification of several exemplars with potent inhibition (EC50 < 100 nM) of HCV, low cytotoxicity (CC50 > 25 µM), and excellent selectivity (selective index = CC50/EC50, > 371-fold). The structure–activity studies culminated in the design and synthesis of a 45-compound library to comprehensively explore the anti-HCV activity. The identification, design, synthesis, and biological characterization for this benzofuran series is discussed.en_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectHepatitis Cen_US
dc.subjectHCV inhibitoren_US
dc.subjectBenzofuranen_US
dc.subjectAntiviralen_US
dc.subjectHcv replicationen_US
dc.titleHigh-Throughput Screening, Discovery, and Optimization to Develop a Benzofuran Class of Hepatitis C Virus Inhibitorsen_US
dc.typeArticleen_US
kusw.kuauthorNeuenswander, Benjamin
kusw.kuauthorAubé, Jeffrey
kusw.kuauthorSchoenen, Frank J.
kusw.kudepartmentHiguchi Biosciences Centeren_US
kusw.kudepartmentMedicinal Chemistryen_US
kusw.kudepartmentHiguchi Biosciences Centeren_US
dc.identifier.doi10.1021/acscombsci.5b00101en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6015500en_US
dc.rights.accessrightsopenAccessen_US


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