ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Centromere-associated meiotic drive and female fitness variation in Mimulus
dc.contributor.author | Fishman, Lila | |
dc.contributor.author | Kelly, John K. | |
dc.date.accessioned | 2018-06-11T16:33:03Z | |
dc.date.available | 2018-06-11T16:33:03Z | |
dc.date.issued | 2015-03 | |
dc.identifier.citation | Fishman, L., & Kelly, J. K. (2015). Centromere-associated meiotic drive and female fitness variation in Mimulus. Evolution; International Journal of Organic Evolution, 69(5), 1208–1218. http://doi.org/10.1111/evo.12661 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/26486 | |
dc.description | This is the peer reviewed version of the following article: Fishman, L. and Kelly, J. K. (2015), Centromere‐associated meiotic drive and female fitness variation in Mimulus. Evolution, 69: 1208-1218. doi:10.1111/evo.12661, which has been published in final form at http://doi.org/10.1111/evo.12661. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en_US |
dc.description.abstract | Female meiotic drive, in which chromosomal variants preferentially segregate to the egg pole during asymmetric female meiosis, is a theoretically pervasive but still mysterious form of selfish evolution. Like other selfish genetic elements, driving chromosomes may be maintained as balanced polymorphisms by pleiotropic or linked fitness costs. A centromere-associated driver (D) with a ~58:42 female-specific transmission advantage occurs at intermediate frequency (32–40%) in the Iron Mountain population of the yellow monkeyflower, Mimulus guttatus. Previously determined male fertility costs are sufficient to prevent the fixation of D, but predict a higher equilibrium frequency. To better understand the dynamics and effects of D, we developed a new population genetic model and measured genotype-specific lifetime female fitness in the wild. In three of four years, and across all years, D imposed significant recessive seedset costs, most likely due to hitchhiking by deleterious mutations. With both male and female costs as measured, and 58:42 drive, our model predicts an equilibrium frequency of D (38%) very close to the observed value. Thus, D represents a rare selfish genetic element whose local population genetic dynamics have been fully parameterized, and the observation of equilibrium sets the stage for investigations of coevolution with suppressors. | en_US |
dc.publisher | Wiley | en_US |
dc.subject | Balancing selection | en_US |
dc.subject | Centromere | en_US |
dc.subject | Genetic conflict | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Seedset | en_US |
dc.subject | Selfish genetic element | en_US |
dc.subject | Standing variation | en_US |
dc.title | Centromere-associated meiotic drive and female fitness variation in Mimulus | en_US |
dc.type | Article | en_US |
kusw.kudepartment | Ecology and Evolutionary | en_US |
dc.identifier.doi | 10.1111/evo.12661 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |