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    Centromere-associated meiotic drive and female fitness variation in Mimulus

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    Issue Date
    2015-03
    Author
    Fishman, Lila
    Kelly, John K.
    Publisher
    Wiley
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Female meiotic drive, in which chromosomal variants preferentially segregate to the egg pole during asymmetric female meiosis, is a theoretically pervasive but still mysterious form of selfish evolution. Like other selfish genetic elements, driving chromosomes may be maintained as balanced polymorphisms by pleiotropic or linked fitness costs. A centromere-associated driver (D) with a ~58:42 female-specific transmission advantage occurs at intermediate frequency (32–40%) in the Iron Mountain population of the yellow monkeyflower, Mimulus guttatus. Previously determined male fertility costs are sufficient to prevent the fixation of D, but predict a higher equilibrium frequency. To better understand the dynamics and effects of D, we developed a new population genetic model and measured genotype-specific lifetime female fitness in the wild. In three of four years, and across all years, D imposed significant recessive seedset costs, most likely due to hitchhiking by deleterious mutations. With both male and female costs as measured, and 58:42 drive, our model predicts an equilibrium frequency of D (38%) very close to the observed value. Thus, D represents a rare selfish genetic element whose local population genetic dynamics have been fully parameterized, and the observation of equilibrium sets the stage for investigations of coevolution with suppressors.
    Description
    This is the peer reviewed version of the following article: Fishman, L. and Kelly, J. K. (2015), Centromere‐associated meiotic drive and female fitness variation in Mimulus. Evolution, 69: 1208-1218. doi:10.1111/evo.12661, which has been published in final form at http://doi.org/10.1111/evo.12661. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    URI
    http://hdl.handle.net/1808/26486
    DOI
    https://doi.org/10.1111/evo.12661
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    • Ecology & Evolutionary Biology Scholarly Works [1493]
    Citation
    Fishman, L., & Kelly, J. K. (2015). Centromere-associated meiotic drive and female fitness variation in Mimulus. Evolution; International Journal of Organic Evolution, 69(5), 1208–1218. http://doi.org/10.1111/evo.12661

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    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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