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    Polymeric Nanohybrids as a New Class of Therapeutic Biotransporters

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    Whitlow_2016.pdf (1.310Mb)
    Issue Date
    2016-06
    Author
    Whitlow, Jonathan
    Pacelli, Settimio
    Paul, Arghya
    Publisher
    Wiley
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    A possible solution to enhance existing drug and gene therapies is to develop hybrid nanocarriers capable of delivering therapeutic agents in a controlled and targeted manner. This goal can be achieved by designing nanohybrid systems, which combine organic or inorganic nanomaterials with biomacromolecules into a single composite. The unique combination of properties along with their facile fabrication enables the design of smart carriers for both drug and gene delivery. These hybrids can be further modified with cell targeting motifs to enhance their biological interactivity. In this Talents and Trends article, an overview of emerging nanohybrid-based technologies will be provided to highlight their potential use as innovative platforms for improved cancer therapies and new strategies in regenerative medicine. The clinical relevance of these systems will be reviewed to define the current challenges which still need to be addressed to allow these therapies to move from bench to bedside.
    Description
    This is the peer reviewed version of the following article: Macromol Chem Phys. 2016 Jun; 217(11): 1245–1259., which has been published in final form at http://doi.org/10.1002/macp.201500464. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    URI
    http://hdl.handle.net/1808/25854
    DOI
    https://doi.org/10.1002/macp.201500464
    Collections
    • Chemical & Petroleum Engineering Scholarly Works [177]
    Citation
    Whitlow, J., Pacelli, S., & Paul, A. (2016). Polymeric Nanohybrids as a New Class of Therapeutic Biotransporters. Macromolecular Chemistry and Physics, 217(11), 1245–1259. http://doi.org/10.1002/macp.201500464

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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