| dc.contributor.advisor | Xu, Liang | |
| dc.contributor.author | Guo, Yuxiao | |
| dc.date.accessioned | 2018-01-30T03:18:46Z | |
| dc.date.available | 2018-01-30T03:18:46Z | |
| dc.date.issued | 2017-05-31 | |
| dc.date.submitted | 2017 | |
| dc.identifier.other | http://dissertations.umi.com/ku:15109 | |
| dc.identifier.uri | http://hdl.handle.net/1808/25812 | |
| dc.description.abstract | It has been reported that long non-coding RNA lincRNA-p21 is induced upon radiation and chemotherapy. This induction contributes to DNA-damage repair, cell death and cell cycle regulation. In this study, we focused on Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that lincRNA-p21 is robotically induced upon TXT treatment. Secondly, we observed increased chemoresistance in three different breast cancer cell lines with lincRNA-p21 knockdown. Mechanistically, we found that lincRNA-p21 knockdown lead to decreased cell death during chemotherapy comparing to the negative control. In addition, our work showed that p21 is a downstream target of lincRNA-p21 in human breast cancer cells, and the loss of lincRNA-p21 caused p21 downregulation at both the RNA and protein levels. | |
| dc.format.extent | 27 pages | |
| dc.language.iso | en | |
| dc.publisher | University of Kansas | |
| dc.rights | Copyright held by the author. | |
| dc.subject | Biology | |
| dc.subject | Breast Cancer | |
| dc.subject | Long non-coding RNA | |
| dc.subject | Taxotere | |
| dc.title | Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression | |
| dc.type | Thesis | |
| dc.contributor.cmtemember | Azuma, Mizuki | |
| dc.contributor.cmtemember | Davido, David | |
| dc.thesis.degreeDiscipline | Molecular Biosciences | |
| dc.thesis.degreeLevel | M.A. | |
| dc.identifier.orcid | | |
| dc.rights.accessrights | openAccess | |
