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Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression

dc.contributor.advisorXu, Liang
dc.contributor.authorGuo, Yuxiao
dc.date.accessioned2018-01-30T03:18:46Z
dc.date.available2018-01-30T03:18:46Z
dc.date.issued2017-05-31
dc.date.submitted2017
dc.identifier.otherhttp://dissertations.umi.com/ku:15109
dc.identifier.urihttp://hdl.handle.net/1808/25812
dc.description.abstractIt has been reported that long non-coding RNA lincRNA-p21 is induced upon radiation and chemotherapy. This induction contributes to DNA-damage repair, cell death and cell cycle regulation. In this study, we focused on Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that lincRNA-p21 is robotically induced upon TXT treatment. Secondly, we observed increased chemoresistance in three different breast cancer cell lines with lincRNA-p21 knockdown. Mechanistically, we found that lincRNA-p21 knockdown lead to decreased cell death during chemotherapy comparing to the negative control. In addition, our work showed that p21 is a downstream target of lincRNA-p21 in human breast cancer cells, and the loss of lincRNA-p21 caused p21 downregulation at both the RNA and protein levels.
dc.format.extent27 pages
dc.language.isoen
dc.publisherUniversity of Kansas
dc.rightsCopyright held by the author.
dc.subjectBiology
dc.subjectBreast Cancer
dc.subjectLong non-coding RNA
dc.subjectTaxotere
dc.titleTaxotere suppresses breast cancer growth through inducing lincRNA-p21 expression
dc.typeThesis
dc.contributor.cmtememberAzuma, Mizuki
dc.contributor.cmtememberDavido, David
dc.thesis.degreeDisciplineMolecular Biosciences
dc.thesis.degreeLevelM.A.
dc.identifier.orcid
dc.rights.accessrightsopenAccess


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