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Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial
dc.contributor.author | Singh, Mandeep | |
dc.contributor.author | Lee, Jaehoon | |
dc.contributor.author | Gupta, Neil | |
dc.contributor.author | Gaddam, Srinivas | |
dc.contributor.author | Smith, Bryan K. | |
dc.contributor.author | Wani, Sachin B. | |
dc.contributor.author | Sullivan, Debra K. | |
dc.contributor.author | Rastogi, Amit | |
dc.contributor.author | Bansal, Ajay | |
dc.contributor.author | Donnelly, Joseph E. | |
dc.contributor.author | Sharma, Prateek | |
dc.date.accessioned | 2017-06-27T19:24:46Z | |
dc.date.available | 2017-06-27T19:24:46Z | |
dc.date.issued | 2013-02 | |
dc.identifier.citation | Singh, M., Lee, J., Gupta, N., Gaddam, S., Smith, B. K., Wani, S. B., Sullivan, D. K., Rastogi, A., Bansal, A., Donnelly, J. E. and Sharma, P. (2013), Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: A prospective intervention trial. Obesity, 21: 284–290. doi:10.1002/oby.20279 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24663 | |
dc.description | This is the peer reviewed version of the following article: Singh, M., Lee, J., Gupta, N., Gaddam, S., Smith, B. K., Wani, S. B., Sullivan, D. K., Rastogi, A., Bansal, A., Donnelly, J. E. and Sharma, P. (2013), Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: A prospective intervention trial. Obesity, 21: 284–290. doi:10.1002/oby.20279, which has been published in final form at http://doi.org/10.1002/oby.20279. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en_US |
dc.description.abstract | OBJECTIVE Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms is not clear. Our aim was to measure the impact of weight loss on GERD symptoms. DESIGN AND METHODS In a prospective cohort study at a tertiary referral center, overweight/obese subjects (BMI 25-39.9 kg/m2) were enrolled in a structured weight loss program. Weight loss strategies included dietary modifications, increased physical activity and behavioral changes. At baseline and at 6 months, BMI and waist circumference were measured and all participants completed a validated reflux disease questionnaire. RESULTS A total of 332 adult subjects, mean age 46 years and 66% women were prospectively enrolled. At baseline, the mean body weight, BMI, and waist circumference were 101 (±18) kg, 35 (±5) kg/m2 and 103 (±13) cm. At 6 months, majority of the subjects (97%) lost weight (average weight loss: 13 ± 7.7 kg) and as compared with baseline, there was a significant decrease in the overall prevalence of GERD (15 vs. 37%; P < 0.01) and the mean GERD symptom score (1.8 vs. 5.5; P < 0.01). Overall, 81% of the subjects had reduction in GERD symptom scores; 65% had complete resolution and 15% had partial resolution of reflux symptoms. There was a significant correlation between % body weight loss and reduction in GERD symptom scores (r = 0.17, P < 0.05). CONCLUSIONS In conclusion, the overall prevalence of GERD symptoms is high (37%) in overweight and obese subjects. A structured weight loss program can lead to complete resolution of GERD symptoms in the majority of these subjects. | en_US |
dc.publisher | Wiley | en_US |
dc.title | Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Lee, Jaehoon | |
kusw.kuauthor | Smith, Bryan K. | |
kusw.kuauthor | Donnelly, Joseph E. | |
kusw.kudepartment | Life Span Institute | en_US |
dc.identifier.doi | 10.1002/oby.20279 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC3853378 | en_US |
dc.rights.accessrights | openAccess |
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