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dc.contributor.authorCai, Sumin
dc.contributor.authorLi, Qing-Shan
dc.contributor.authorFang, Jianwen
dc.contributor.authorBorchardt, Ronald T.
dc.contributor.authorKuczera, Krzysztof
dc.contributor.authorMiddaugh, C. Russell
dc.contributor.authorSchowen, Richard L.
dc.date.accessioned2017-06-27T18:48:52Z
dc.date.available2017-06-27T18:48:52Z
dc.date.issued2009-05
dc.identifier.citationCai, S., Li, Q.-S., Fang, J., Borchardt, R. T., Kuczera, K., Middaugh, C. R., & Schowen, R. L. (2009). The Rationale for Targeting the NAD/NADH Cofactor Binding Site of Parasitic S-Adenosyl-L-homocysteine Hydrolase for the Design of Anti-parasitic Drugs. Nucleosides, Nucleotides & Nucleic Acids, 28(5), 485–503. http://doi.org/10.1080/15257770903051031en_US
dc.identifier.urihttp://hdl.handle.net/1808/24659
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids in May 2009, available online: http://www.tandfonline.com/10.1080/15257770903051031.en_US
dc.description.abstractTrypanosomal S-adenoyl-L-homocysteine hydrolase (Tc-SAHH), considered as a target for treatment of Chagas disease, has the same catalytic mechanism as human SAHH (Hs-SAHH) and both enzymes have very similar X-ray structures. Efforts toward the design of selective inhibitors against Tc-SAHH targeting the substrate binding site have not to date shown any significant promise. Systematic kinetic and thermodynamic studies on association and dissociation of cofactor NAD/H for Tc-SAHH and Hs-SAHH provide a rationale for the design of anti-parasitic drugs directed toward cofactor-binding sites. Analogues of NAD and their reduced forms show significant selective inactivation of Tc-SAHH, confirming that this design approach is rational.en_US
dc.publisherTaylor & Francisen_US
dc.titleThe Rationale for Targeting the NAD/NADH Cofactor Binding Site of Parasitic S-Adenosyl-L-homocysteine Hydrolase for the Design of Anti-parasitic Drugsen_US
dc.typeArticleen_US
kusw.kuauthorCai, Sumin
kusw.kuauthorLi, Qing-Shan
kusw.kuauthorFang, Jianwen
kusw.kuauthorBorchardt, Ronald T.
kusw.kuauthorKuczera, Krzysztof
kusw.kuauthorMiddaugh, C. Russell
kusw.kuauthorSchowen, Richard L.
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1080/15257770903051031en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4128003en_US
dc.rights.accessrightsopenAccess


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