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dc.contributor.authorMiller, Benjamin R.
dc.contributor.authorWalker, Adam G.
dc.contributor.authorFowler, Stephen C.
dc.contributor.authorvon Hörsten, Stephan
dc.contributor.authorRiess, Olaf
dc.contributor.authorJohnson, Michael A.
dc.contributor.authorRebec, George V.
dc.date.accessioned2017-06-27T17:00:26Z
dc.date.available2017-06-27T17:00:26Z
dc.date.issued2010-01
dc.identifier.citationMiller, B. R., Walker, A. G., Fowler, S. C., von Hörsten, S., Riess, O., Johnson, M. A., & Rebec, G. V. (2010). Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington’s disease. Neurobiology of Disease, 37(1), 106–113. http://doi.org/10.1016/j.nbd.2009.09.013en_US
dc.identifier.urihttp://hdl.handle.net/1808/24647
dc.description.abstractAltered neuronal activity in the striatum appears to be a key component of Huntington’s disease (HD), a fatal, neurodegenerative condition. To assess this hypothesis in freely behaving transgenic rats that model HD (tgHDs), we used chronically implanted micro-wires to record the spontaneous activity of striatal neurons. We found that relative to wild-type controls, HD rats suffer from population-level deficits in striatal activity characterized by a loss of correlated firing and fewer episodes of coincident spike bursting between simultaneously recorded neuronal pairs. These results are in line with our previous report of marked alterations in the pattern of striatal firing in mouse models of HD that vary in background strain, genetic construct, and symptom severity. Thus, loss of coordinated spike activity in striatum appears to be a common feature of HD pathophysiology, regardless of HD model variability.en_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectHuntington’s diseaseen_US
dc.subjectTransgenicen_US
dc.subjectRaten_US
dc.subjectStriatumen_US
dc.subjectMedium spiny neuronsen_US
dc.subjectElectrophysiologyen_US
dc.subjectCross-correlationen_US
dc.subjectBursten_US
dc.subjectBasal gangliaen_US
dc.titleDysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington’s diseaseen_US
dc.typeArticleen_US
kusw.kuauthorFowler, Stephen C.
kusw.kuauthorJohnson, Michael A.
kusw.kudepartmentLife Span Instituteen_US
dc.identifier.doi10.1016/j.nbd.2009.09.013en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2787873en_US
dc.rights.accessrightsopenAccess


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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.