dc.contributor.author | Zhao, Yunqi | |
dc.contributor.author | Zhang, Ti | |
dc.contributor.author | Duan, Shaofeng | |
dc.contributor.author | Davies, Neal M. | |
dc.contributor.author | Forrest, M. Laird | |
dc.date.accessioned | 2017-06-27T16:36:53Z | |
dc.date.available | 2017-06-27T16:36:53Z | |
dc.date.issued | 2014-08 | |
dc.identifier.citation | Zhao, Y., Zhang, T., Duan, S., Davies, N. M., & Forrest, M. L. (2014). CD44-Tropic Polymeric Nanocarrier for Breast Cancer Targeted Rapamycin Chemotherapy. Nanomedicine : Nanotechnology, Biology, and Medicine, 10(6), 1221–1230. http://doi.org/10.1016/j.nano.2014.02.015 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24644 | |
dc.description.abstract | In contrast with the conventional targeting of nanoparticles to cancer cells with antibody or peptide conjugates, a hyaluronic acid (HA) matrix nanoparticle with intrinsic-CD44-tropism was developed to deliver rapamycin for localized CD44-positive breast cancer treatment. Rapamycin was chemically conjugated to the particle surface via a novel sustained-release linker, 3-amino-4-methoxy-benzoic acid. The release of the drug from the HA nanoparticle was improved by 42-fold compared to HA-temsirolimus in buffered saline. In CD44 positive MDA-MB-468 cells, using HA as drug delivery carrier, the cell-viability was significantly decreased compared to free rapamycin and CD44-blocked controls. Rat pharmacokinetics showed that the area-under-the-curve of HA nanoparticle formulation was 2.96-fold greater than that of the free drug, and the concomitant total body clearance was 8.82-fold slower. Moreover, in immunocompetent BALB/c mice bearing CD44-positive 4T1.2neu breast cancer, the rapamycin1loaded HA particles significantly improved animal survival, suppressed tumor growth and reduced the prevalence of lung metastasis. | en_US |
dc.publisher | Future Medicine | en_US |
dc.subject | Hyaluronic acid | en_US |
dc.subject | Rapamycin | en_US |
dc.subject | CD44 | en_US |
dc.subject | Breast Cancer | en_US |
dc.title | CD44-Tropic Polymeric Nanocarrier for Breast Cancer Targeted Rapamycin Chemotherapy | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Zhoa, Yunqi | |
kusw.kuauthor | Zhang, Ti | |
kusw.kuauthor | Duan, Shaofeng | |
kusw.kuauthor | Forrest, M. Laird | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.1016/j.nano.2014.02.015 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC4119834 | en_US |
dc.rights.accessrights | openAccess | |