LipidomeDB Data Calculation Environment: Online Processing of Direct-Infusion Mass Spectral Data for Lipid Profiles

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Issue Date
2011-09Author
Zhou, Zhenguo
Marepally, Shantan Reddy
Nune, Daya Sagar
Pallakollu, Prashanth
Ragan, Gail
Roth, Mary R.
Wang, Liangjiang
Lushington, Gerald H.
Visvanathan, Mahesh
Welti, Ruth
Publisher
Springer Verlag
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Metadata
Show full item recordAbstract
LipidomeDB Data Calculation Environment (DCE) is a web application to quantify complex lipids by processing data acquired after direct infusion of a lipid-containing biological extract, to which a cocktail of internal standards has been added, into an electrospray source of a triple quadrupole mass spectrometer. LipidomeDB DCE is located on the public Internet at http://lipidome.bcf.ku.edu:9000/Lipidomics. LipidomeDB DCE supports targeted analyses; analyte information can be entered, or pre-formulated lists of typical plant or animal polar lipid analytes can be selected. LipidomeDB DCE performs isotopic deconvolution and quantification in comparison to internal standard spectral peaks. Multiple precursor or neutral loss spectra from up to 35 samples may be processed simultaneously with data input as Excel files and output as tables viewable on the web and exportable in Excel. The pre-formulated compound lists and web access, used with direct-infusion mass spectrometry, provide a simple approach to lipidomic analysis, particularly for new users.
Description
The final publication is available at Springer via http://dx.doi.org/10.1007/s11745-011-3575-8.
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Citation
Zhou, Z., Marepally, S. R., Nune, D. S., Pallakollu, P., Ragan, G., Roth, M. R., … Welti, R. (2011). LipidomeDB Data Calculation Environment: Online Processing of Direct-Infusion Mass Spectral Data for Lipid Profiles. Lipids, 46(9), 879–884. http://doi.org/10.1007/s11745-011-3575-8
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