Osteochondral Interface Regeneration of the Rabbit Mandibular Condyle with Bioactive Signal Gradients

Dormer, Nathan Henry; Busaidy, Kamal; Berkland, Cory J.; Detamore, Michael S.

dc.contributor.author	Dormer, Nathan Henry
dc.contributor.author	Busaidy, Kamal
dc.contributor.author	Berkland, Cory J.
dc.contributor.author	Detamore, Michael S.
dc.date.accessioned	2017-06-15T14:35:20Z
dc.date.available	2017-06-15T14:35:20Z
dc.date.issued	2011-06
dc.identifier.citation	Dormer, N. H., Busaidy, K., Berkland, C. J., & Detamore, M. S. (2011). OSTEOCHONDRAL INTERFACE REGENERATION OF THE RABBIT MANDIBULAR CONDYLE WITH BIOACTIVE SIGNAL GRADIENTS. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons, 69(6), e50–e57. http://doi.org/10.1016/j.joms.2010.12.049	en_US
dc.identifier.uri	http://hdl.handle.net/1808/24511
dc.description.abstract	PURPOSE Tissue engineering solutions focused on the temporomandibular joint (TMJ) have expanded in number and variety over the past decade to address the treatment of TMJ disorders. The existing literature on approaches for healing small defects in the TMJ condylar cartilage and subchondral bone, however, is sparse. The purpose of this study was thus to evaluate the performance of a novel gradient-based scaffolding approach to regenerate osteochondral defects in the rabbit mandibular condyle. MATERIALS AND METHODS Miniature bioactive plugs for regeneration of small mandibular condylar defects in New Zealand White rabbits were fabricated. The plugs were constructed from poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres with a gradient transition between cartilage-promoting and bone-promoting growth factors. RESULTS At six weeks of healing, results suggested that the implants provided support for the neo-synthesized tissue as evidenced by histology and 9.4T magnetic resonance imaging. CONCLUSION The inclusion of bioactive factors in a gradient-based scaffolding design is a promising new treatment strategy for focal defect repair in the TMJ.	en_US
dc.publisher	WB Saunders	en_US
dc.rights	© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/	en_US
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	en_US
dc.subject	TMJ	en_US
dc.subject	Osteochondral	en_US
dc.subject	Interface	en_US
dc.subject	Gradient	en_US
dc.subject	Microsphere	en_US
dc.subject	PLGA	en_US
dc.subject	BMP-2	en_US
dc.subject	TGF-β1	en_US
dc.title	Osteochondral Interface Regeneration of the Rabbit Mandibular Condyle with Bioactive Signal Gradients	en_US
dc.type	Article	en_US
kusw.kuauthor	Dormer, Nathan H.
kusw.kuauthor	Berkland, Cory J.
kusw.kuauthor	Detamore, Michael S.
kusw.kudepartment	Bioengineering	en_US
kusw.oanotes	Per SHERPA/RoMEO 6/15/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions: Pre-print allowed on any website or open access repository Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists. Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months Set statement to accompany deposit Published source must be acknowledged Must link to journal home page or articles' DOI Publisher's version/PDF cannot be used Articles in some journals can be made Open Access on payment of additional charge NIH Authors articles will be submitted to PubMed Central after 12 months Authors who are required to deposit in subject-based repositories may also use Sponsorship Option	en_US
dc.identifier.doi	10.1016/j.joms.2010.12.049	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC3101307	en_US
dc.rights.accessrights	openAccess

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