Anti-Arthritic Effects and Toxicity of the Essential Oils of Turmeric (Curcuma longa L.)

Funk, Janet L.; Frye, Jennifer B.; Oyarzo, Janice N.; Zhang, Huaping; Timmermann, Barbara N.

dc.contributor.author	Funk, Janet L.
dc.contributor.author	Frye, Jennifer B.
dc.contributor.author	Oyarzo, Janice N.
dc.contributor.author	Zhang, Huaping
dc.contributor.author	Timmermann, Barbara N.
dc.date.accessioned	2017-06-14T20:56:24Z
dc.date.available	2017-06-14T20:56:24Z
dc.date.issued	2010-01-27
dc.identifier.citation	Funk, J. L., Frye, J. B., Oyarzo, J. N., Zhang, H., & Timmermann, B. N. (2010). Anti-Arthritic Effects and Toxicity of the Essential Oils of Turmeric (Curcuma longa L.). Journal of Agricultural and Food Chemistry, 58(2), 842–849. http://doi.org/10.1021/jf9027206	en_US
dc.identifier.uri	http://hdl.handle.net/1808/24505
dc.description	This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/jf9027206.	en_US
dc.description.abstract	Abstract Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Having previously identified potent anti-arthritic effects of the curcuminoids in turmeric extracts in an animal model of rheumatoid arthritis (RA), studies were undertaken to determine whether the turmeric essential oils (TEO) were also joint protective using the same experimental model. Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was non-toxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment, but, instead, identify potential safety concerns in vertebrates exposed to TEO.	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Curcuma longa L.	en_US
dc.subject	Turmeric	en_US
dc.subject	Essential oil	en_US
dc.subject	Arthritis	en_US
dc.subject	Rheumatoid arthritis	en_US
dc.subject	Liver	en_US
dc.subject	Anemia	en_US
dc.title	Anti-Arthritic Effects and Toxicity of the Essential Oils of Turmeric (Curcuma longa L.)	en_US
dc.type	Article	en_US
kusw.kuauthor	Zhang, Huaping
kusw.kuauthor	Timmermann, Barbara N.
kusw.kudepartment	Medicinal Chemistry	en_US
dc.identifier.doi	10.1021/jf9027206	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC2834817	en_US
dc.rights.accessrights	openAccess

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