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    Anti-Arthritic Effects and Toxicity of the Essential Oils of Turmeric (Curcuma longa L.)

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    Zhang_2010.pdf (545.9Kb)
    Issue Date
    2010-01-27
    Author
    Funk, Janet L.
    Frye, Jennifer B.
    Oyarzo, Janice N.
    Zhang, Huaping
    Timmermann, Barbara N.
    Publisher
    American Chemical Society
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Abstract

    Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Having previously identified potent anti-arthritic effects of the curcuminoids in turmeric extracts in an animal model of rheumatoid arthritis (RA), studies were undertaken to determine whether the turmeric essential oils (TEO) were also joint protective using the same experimental model. Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was non-toxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment, but, instead, identify potential safety concerns in vertebrates exposed to TEO.
    Description
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/jf9027206.
    URI
    http://hdl.handle.net/1808/24505
    DOI
    https://doi.org/10.1021/jf9027206
    Collections
    • Medicinal Chemistry Scholarly Works [248]
    Citation
    Funk, J. L., Frye, J. B., Oyarzo, J. N., Zhang, H., & Timmermann, B. N. (2010). Anti-Arthritic Effects and Toxicity of the Essential Oils of Turmeric (Curcuma longa L.). Journal of Agricultural and Food Chemistry, 58(2), 842–849. http://doi.org/10.1021/jf9027206

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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